Selenium is found at the active centre of twenty-five selenoproteins which have a variety of roles, including the well-characterised function of antioxidant defense, but it also is claimed to be involved in the immune system. However, due to limited and conflicting data for different parameters of immune function, intakes of selenium that have an influence on immune function are uncertain. This review covers the relationship between selenium and immune function in man, focusing on the highest level of evidence, namely that generated by randomized controlled trials (RCTs), in which the effect of selective administration of selenium, in foods or a supplement, on immune function was assessed. A total of nine RCTs were identified from a systematic search of the literature, and some of these trials reported effects on T and NK cells, which were dependent on the dose and form of selenium administered, but little effect of selenium on humoral immunity. There is clearly a need to undertake dose-response analysis of cellular immunity data in order to derive quantitative relationships between selenium intake and measures of immune function. Overall, limited effects on immunity emerged from experimental studies in humans, though additional investigation on the potential influence of selenium status on cellular immunity appears to be warranted.

Selenium status and immunity / Fairweather-Tait, Susan J; Filippini, Tommaso; Vinceti, Marco. - In: PROCEEDINGS OF THE NUTRITION SOCIETY. - ISSN 0029-6651. - (2022), pp. 1-7. [10.1017/S0029665122002658]

Selenium status and immunity

Filippini, Tommaso;Vinceti, Marco
2022-01-01

Abstract

Selenium is found at the active centre of twenty-five selenoproteins which have a variety of roles, including the well-characterised function of antioxidant defense, but it also is claimed to be involved in the immune system. However, due to limited and conflicting data for different parameters of immune function, intakes of selenium that have an influence on immune function are uncertain. This review covers the relationship between selenium and immune function in man, focusing on the highest level of evidence, namely that generated by randomized controlled trials (RCTs), in which the effect of selective administration of selenium, in foods or a supplement, on immune function was assessed. A total of nine RCTs were identified from a systematic search of the literature, and some of these trials reported effects on T and NK cells, which were dependent on the dose and form of selenium administered, but little effect of selenium on humoral immunity. There is clearly a need to undertake dose-response analysis of cellular immunity data in order to derive quantitative relationships between selenium intake and measures of immune function. Overall, limited effects on immunity emerged from experimental studies in humans, though additional investigation on the potential influence of selenium status on cellular immunity appears to be warranted.
1
7
Selenium status and immunity / Fairweather-Tait, Susan J; Filippini, Tommaso; Vinceti, Marco. - In: PROCEEDINGS OF THE NUTRITION SOCIETY. - ISSN 0029-6651. - (2022), pp. 1-7. [10.1017/S0029665122002658]
Fairweather-Tait, Susan J; Filippini, Tommaso; Vinceti, Marco
File in questo prodotto:
File Dimensione Formato  
selenium-status-and-immunity-2.pdf

non disponibili

Tipologia: Versione pubblicata dall'editore
Dimensione 1.07 MB
Formato Adobe PDF
1.07 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1285305
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact