GRADE guidance to rate the certainty domain of imprecision is presently not fully operationalized for rating down by two levels and when different or uncertainty in baseline risks are considered. In addition, there are scenarios in which lowering the certainty of evidence by three levels for imprecision is more appropriate than lowering it by two levels. In this article, we conceptualize and operationalize rating down for imprecision by one, two and three levels for imprecision using the contextualized GRADE approaches.
GRADE Guidance article 35: Update on rating imprecision for assessing contextualized certainty of evidence and making decisions / Schünemann, Holger J; Neumann, Ignacio; Hultcrantz, Monica; Brignardello-Petersen, Romina; Zeng, Linan; Murad, M Hassan; Izcovich, Ariel; Morgano, Gian Paolo; Baldeh, Tejan; Santesso, Nancy; Cuello, Carlos Garcia; Mbuagbaw, Lawrence; Guyatt, Gordon; Wiercioch, Wojtek; Piggott, Thomas; De Beer, Hans; Vinceti, Marco; Mathioudakis, Alexander G; Mayer, Martin G; Mustafa, Reem; Filippini, Tommaso; Iorio, Alfonso; Nieuwlaat, Robby; Marcucci, Maura; Coello, Pablo Alonso; Bonovas, Stefanos; Piovani, Daniele; Tomlinson, George; Akl, Elie A. - In: JOURNAL OF CLINICAL EPIDEMIOLOGY. - ISSN 0895-4356. - 150:(2022), pp. 225-242. [10.1016/j.jclinepi.2022.07.015]
GRADE Guidance article 35: Update on rating imprecision for assessing contextualized certainty of evidence and making decisions
Vinceti, Marco;Filippini, Tommaso;
2022
Abstract
GRADE guidance to rate the certainty domain of imprecision is presently not fully operationalized for rating down by two levels and when different or uncertainty in baseline risks are considered. In addition, there are scenarios in which lowering the certainty of evidence by three levels for imprecision is more appropriate than lowering it by two levels. In this article, we conceptualize and operationalize rating down for imprecision by one, two and three levels for imprecision using the contextualized GRADE approaches.
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