The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10% of people with previously documented infection may develop PACS, and up to 50-80% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.

The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach / Guaraldi, Giovanni; Milic, Jovana; Cesari, Matteo; Leibovici, Leonard; Mandreoli, Federica; Missier, Paolo; Rozzini, Renzo; Cattelan, Anna Maria; Motta, Federico; Mussini, Cristina; Cossarizza, Andrea. - In: AGEING RESEARCH REVIEWS. - ISSN 1568-1637. - 81:(2022), pp. N/A-N/A. [10.1016/j.arr.2022.101686]

The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach

Guaraldi, Giovanni
;
Mandreoli, Federica;Motta, Federico;Mussini, Cristina;Cossarizza, Andrea
2022-01-01

Abstract

The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10% of people with previously documented infection may develop PACS, and up to 50-80% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.
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The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach / Guaraldi, Giovanni; Milic, Jovana; Cesari, Matteo; Leibovici, Leonard; Mandreoli, Federica; Missier, Paolo; Rozzini, Renzo; Cattelan, Anna Maria; Motta, Federico; Mussini, Cristina; Cossarizza, Andrea. - In: AGEING RESEARCH REVIEWS. - ISSN 1568-1637. - 81:(2022), pp. N/A-N/A. [10.1016/j.arr.2022.101686]
Guaraldi, Giovanni; Milic, Jovana; Cesari, Matteo; Leibovici, Leonard; Mandreoli, Federica; Missier, Paolo; Rozzini, Renzo; Cattelan, Anna Maria; Motta, Federico; Mussini, Cristina; Cossarizza, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1283860
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