Introduction: Aims of the study were to explore outcomes and toxicities of chemotherapy-immunotherapy (CT-IT) for patients (pts) with metastatic nonsquamous non-small-cell lung cancer (mNSCLC) in a real-world population. Materials & methods: Clinical data of 26 pts with mNSCLC treated with CT-IT at our institution from January 2020 to January 2021 were collected retrospectively. Results: Median follow-up time was 7.7 months. Median progression-free survival was 9.5 months. The most frequent immune-related adverse event was thyroid dysfunction (ThD): 30.7%. Conclusion: There was a higher rate of ThD in this study population compared with the literature, with a possible correlation with clinical outcomes. Plain language summary Aims of the study were to explore outcomes and toxicities of chemotherapy-immunotherapy (CT-IT) for patients (pts) with metastatic nonsquamous NSCLC (mNSCLC) in a real practice experience, because practice experience not always could be the same of experimental experience. We collected clinical data of 26 pts with mNSCLC, treated with CT-IT at our Institution from January 2020 to January 2021. We observed efficacy and tolerability of treatment were similar to known data, except for thyroid disfunctions (ThD) that was more frequent in our experience. This collateral effect was not cause of treatment interruption, indeed the pts with this manifestation would seem responder better to this therapy. However, we need more time and kind of studies for confirm this observation.

Thyroid function impairment after chemo-immunotherapy for advanced NSCLC: A single institutional retrospective report / Trudu, L.; Guaitoli, G.; Bertolini, F.; Maur, M.; Santini, C.; Papapietro, V. R.; Talerico, S.; Natalizio, S.; Isca, C.; Dominici, M.; Barbieri, F.. - In: IMMUNOTHERAPY. - ISSN 1750-743X. - 14:9(2022), pp. 675-682. [10.2217/imt-2021-0165]

Thyroid function impairment after chemo-immunotherapy for advanced NSCLC: A single institutional retrospective report

Trudu L.;Guaitoli G.;Maur M.;Santini C.;Papapietro V. R.;Talerico S.;Natalizio S.;Isca C.;Dominici M.;
2022

Abstract

Introduction: Aims of the study were to explore outcomes and toxicities of chemotherapy-immunotherapy (CT-IT) for patients (pts) with metastatic nonsquamous non-small-cell lung cancer (mNSCLC) in a real-world population. Materials & methods: Clinical data of 26 pts with mNSCLC treated with CT-IT at our institution from January 2020 to January 2021 were collected retrospectively. Results: Median follow-up time was 7.7 months. Median progression-free survival was 9.5 months. The most frequent immune-related adverse event was thyroid dysfunction (ThD): 30.7%. Conclusion: There was a higher rate of ThD in this study population compared with the literature, with a possible correlation with clinical outcomes. Plain language summary Aims of the study were to explore outcomes and toxicities of chemotherapy-immunotherapy (CT-IT) for patients (pts) with metastatic nonsquamous NSCLC (mNSCLC) in a real practice experience, because practice experience not always could be the same of experimental experience. We collected clinical data of 26 pts with mNSCLC, treated with CT-IT at our Institution from January 2020 to January 2021. We observed efficacy and tolerability of treatment were similar to known data, except for thyroid disfunctions (ThD) that was more frequent in our experience. This collateral effect was not cause of treatment interruption, indeed the pts with this manifestation would seem responder better to this therapy. However, we need more time and kind of studies for confirm this observation.
14
9
675
682
Thyroid function impairment after chemo-immunotherapy for advanced NSCLC: A single institutional retrospective report / Trudu, L.; Guaitoli, G.; Bertolini, F.; Maur, M.; Santini, C.; Papapietro, V. R.; Talerico, S.; Natalizio, S.; Isca, C.; Dominici, M.; Barbieri, F.. - In: IMMUNOTHERAPY. - ISSN 1750-743X. - 14:9(2022), pp. 675-682. [10.2217/imt-2021-0165]
Trudu, L.; Guaitoli, G.; Bertolini, F.; Maur, M.; Santini, C.; Papapietro, V. R.; Talerico, S.; Natalizio, S.; Isca, C.; Dominici, M.; Barbieri, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1281098
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