Aims: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. Methods: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. Results: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n = 77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n = 114; p = 0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. Conclusions: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded. © 2010.

Potential celiac disease in type 1 diabetes: A multicenter study / Franzese, A.; Iafusco, D.; Spadaro, R.; Cavaliere, O.; Prisco, F.; Auricchio, R.; Troncone, R.; Valerio, G.; Lera, R.; Fontana, F.; Cherubini, V.; Biagioni, M.; Pasquino, B.; Gallo, F.; Suprani, T.; Tumini, S.; Lazzaro, N.; Toni, S.; D'Annunzio, G.; Emmanuele, V.; Bruzzese, M.; Lombardo, F.; Bonfanti, R.; Tronconi, G. M.; Iughetti, L.; Monciotti, C.; Cardella, F.; Chiari, G.; Vanelli, M.; Calcaterra, V.; Federico, G.; Crino, A.; Cappa, M.; Patera, I.; Negro, I.; Delvecchio, M.; Rabbone, I.; Guerraggio, L.; Salvatoni, A.; Costantini, C.; Pinelli, L.. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - 92:1(2011), pp. 53-56. [10.1016/j.diabres.2010.12.028]

Potential celiac disease in type 1 diabetes: A multicenter study

Valerio G.;Lera R.;Gallo F.;Tumini S.;Lombardo F.;Iughetti L.;Cappa M.;Pinelli L.
2011

Abstract

Aims: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. Methods: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. Results: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n = 77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n = 114; p = 0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. Conclusions: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded. © 2010.
92
1
53
56
Potential celiac disease in type 1 diabetes: A multicenter study / Franzese, A.; Iafusco, D.; Spadaro, R.; Cavaliere, O.; Prisco, F.; Auricchio, R.; Troncone, R.; Valerio, G.; Lera, R.; Fontana, F.; Cherubini, V.; Biagioni, M.; Pasquino, B.; Gallo, F.; Suprani, T.; Tumini, S.; Lazzaro, N.; Toni, S.; D'Annunzio, G.; Emmanuele, V.; Bruzzese, M.; Lombardo, F.; Bonfanti, R.; Tronconi, G. M.; Iughetti, L.; Monciotti, C.; Cardella, F.; Chiari, G.; Vanelli, M.; Calcaterra, V.; Federico, G.; Crino, A.; Cappa, M.; Patera, I.; Negro, I.; Delvecchio, M.; Rabbone, I.; Guerraggio, L.; Salvatoni, A.; Costantini, C.; Pinelli, L.. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - 92:1(2011), pp. 53-56. [10.1016/j.diabres.2010.12.028]
Franzese, A.; Iafusco, D.; Spadaro, R.; Cavaliere, O.; Prisco, F.; Auricchio, R.; Troncone, R.; Valerio, G.; Lera, R.; Fontana, F.; Cherubini, V.; Biagioni, M.; Pasquino, B.; Gallo, F.; Suprani, T.; Tumini, S.; Lazzaro, N.; Toni, S.; D'Annunzio, G.; Emmanuele, V.; Bruzzese, M.; Lombardo, F.; Bonfanti, R.; Tronconi, G. M.; Iughetti, L.; Monciotti, C.; Cardella, F.; Chiari, G.; Vanelli, M.; Calcaterra, V.; Federico, G.; Crino, A.; Cappa, M.; Patera, I.; Negro, I.; Delvecchio, M.; Rabbone, I.; Guerraggio, L.; Salvatoni, A.; Costantini, C.; Pinelli, L.
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