Epstein–Barr virus (EBV) is a common pathogen infecting people primarily early in life. The virus has the ability to persist throughout a person’s life, usually in B lymphocytes. Conditions of immunodeficiency as well as the introduction of immunosuppressive therapies and the advent of transplant technologies has brought immunodeficiency-associated lymphoproliferative disorders into view, which are often driven by EBV. The group of EBV-associated lymphoproliferative disorders includes different entities, with distinct biological features, ranging from indolent disor-ders, which may even spontaneously regress, to aggressive lymphomas requiring prompt and ade-quate treatment. These disorders are often diagnostically challenging due to their overlapping mor-phology and immunophenotype. Both nodal and extra-nodal sites, including the gastrointestinal tract, may be involved. This review, divided in three parts, summarizes the clinical, pathological, molecular features and treatment strategies of EBV-related lymphoproliferative disorders occurring in the gastrointestinal tract and critically analyzes the major issues in the differential diagnosis. In this part of the review, we discuss plasmablastic lymphoma, extra-cavitary primary effusion lymphoma and Burkitt lymphoma.

Ebv-driven lymphoproliferative disorders and lymphomas of the gastrointestinal tract: A spectrum of entities with a common denominator (part 2) / Zanelli, M.; Sanguedolce, F.; Palicelli, A.; Zizzo, M.; Martino, G.; Caprera, C.; Fragliasso, V.; Soriano, A.; Valle, L.; Ricci, S.; Gozzi, F.; Cimino, L.; Cavazza, A.; Merli, F.; Pileri, S. A.; Ascani, S.. - In: CANCERS. - ISSN 2072-6694. - 13:18(2021), pp. 4527-N/A. [10.3390/cancers13184527]

Ebv-driven lymphoproliferative disorders and lymphomas of the gastrointestinal tract: A spectrum of entities with a common denominator (part 2)

Zanelli M.;Zizzo M.;Martino G.;Fragliasso V.;Ricci S.;Cimino L.;Cavazza A.;
2021

Abstract

Epstein–Barr virus (EBV) is a common pathogen infecting people primarily early in life. The virus has the ability to persist throughout a person’s life, usually in B lymphocytes. Conditions of immunodeficiency as well as the introduction of immunosuppressive therapies and the advent of transplant technologies has brought immunodeficiency-associated lymphoproliferative disorders into view, which are often driven by EBV. The group of EBV-associated lymphoproliferative disorders includes different entities, with distinct biological features, ranging from indolent disor-ders, which may even spontaneously regress, to aggressive lymphomas requiring prompt and ade-quate treatment. These disorders are often diagnostically challenging due to their overlapping mor-phology and immunophenotype. Both nodal and extra-nodal sites, including the gastrointestinal tract, may be involved. This review, divided in three parts, summarizes the clinical, pathological, molecular features and treatment strategies of EBV-related lymphoproliferative disorders occurring in the gastrointestinal tract and critically analyzes the major issues in the differential diagnosis. In this part of the review, we discuss plasmablastic lymphoma, extra-cavitary primary effusion lymphoma and Burkitt lymphoma.
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18
4527
N/A
Ebv-driven lymphoproliferative disorders and lymphomas of the gastrointestinal tract: A spectrum of entities with a common denominator (part 2) / Zanelli, M.; Sanguedolce, F.; Palicelli, A.; Zizzo, M.; Martino, G.; Caprera, C.; Fragliasso, V.; Soriano, A.; Valle, L.; Ricci, S.; Gozzi, F.; Cimino, L.; Cavazza, A.; Merli, F.; Pileri, S. A.; Ascani, S.. - In: CANCERS. - ISSN 2072-6694. - 13:18(2021), pp. 4527-N/A. [10.3390/cancers13184527]
Zanelli, M.; Sanguedolce, F.; Palicelli, A.; Zizzo, M.; Martino, G.; Caprera, C.; Fragliasso, V.; Soriano, A.; Valle, L.; Ricci, S.; Gozzi, F.; Cimino, L.; Cavazza, A.; Merli, F.; Pileri, S. A.; Ascani, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1280715
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