Narcolepsy type 1 is a central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy (i.e., sudden loss of muscle tone during wakefulness triggered by emotions), and REM sleep-related manifestations that can present with a peculiar phenotype when arising at a pediatric age. Several features of childhood-onset narcolepsy type 1 are also common in neuropsychiatric conditions; discrete neuropsychiatric comorbidity has also been demonstrated. Here, we report on 3 children with very early narcolepsy type 1. All 3 patients had psychiatric features at the time of symptom onset coupled with peculiar motor disturbances. The course of narcolepsy symptoms also paralleled neuropsychiatric symptoms, suggesting a possible intrinsic link between sleep and psychological features. Multidisciplinary management is mandatory for pediatric narcolepsy type 1 since prompt disease management addressing neuropsychiatric symptoms could lead to better clinical outcomes and quality of life.

Child Neurology: A Case Series of Heterogeneous Neuropsychiatric Symptoms and Outcome in Very Early-Onset Narcolepsy Type 1 / Veneruso, M.; Pizza, F.; Finotti, E.; Amore, G.; Vandi, S.; Filardi, M.; Antelmi, E.; Nobili, L.; Cassio, A.; Pession, A.; Plazzi, G.. - In: NEUROLOGY. - ISSN 0028-3878. - 98:23(2022), pp. 984-989. [10.1212/WNL.0000000000200666]

Child Neurology: A Case Series of Heterogeneous Neuropsychiatric Symptoms and Outcome in Very Early-Onset Narcolepsy Type 1

Plazzi G.
2022

Abstract

Narcolepsy type 1 is a central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy (i.e., sudden loss of muscle tone during wakefulness triggered by emotions), and REM sleep-related manifestations that can present with a peculiar phenotype when arising at a pediatric age. Several features of childhood-onset narcolepsy type 1 are also common in neuropsychiatric conditions; discrete neuropsychiatric comorbidity has also been demonstrated. Here, we report on 3 children with very early narcolepsy type 1. All 3 patients had psychiatric features at the time of symptom onset coupled with peculiar motor disturbances. The course of narcolepsy symptoms also paralleled neuropsychiatric symptoms, suggesting a possible intrinsic link between sleep and psychological features. Multidisciplinary management is mandatory for pediatric narcolepsy type 1 since prompt disease management addressing neuropsychiatric symptoms could lead to better clinical outcomes and quality of life.
2022
98
23
984
989
Child Neurology: A Case Series of Heterogeneous Neuropsychiatric Symptoms and Outcome in Very Early-Onset Narcolepsy Type 1 / Veneruso, M.; Pizza, F.; Finotti, E.; Amore, G.; Vandi, S.; Filardi, M.; Antelmi, E.; Nobili, L.; Cassio, A.; Pession, A.; Plazzi, G.. - In: NEUROLOGY. - ISSN 0028-3878. - 98:23(2022), pp. 984-989. [10.1212/WNL.0000000000200666]
Veneruso, M.; Pizza, F.; Finotti, E.; Amore, G.; Vandi, S.; Filardi, M.; Antelmi, E.; Nobili, L.; Cassio, A.; Pession, A.; Plazzi, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1280610
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