Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00–1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study / Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:6(2021), pp. 585-598. [10.1111/hiv.13210]

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Burke M.;Esposito R.;Mussini C.;Guaraldi G.;
2021

Abstract

Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00–1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.
2021
HIV MEDICINE
23
6
585
598
WOS:000728470000001
2-s2.0-85120965873
The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study / Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:6(2021), pp. 585-598. [10.1111/hiv.13210]
Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.
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