The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.

doi:10.1111/hiv.13210

Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00–1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study / Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:6(2021), pp. 585-598. [10.1111/hiv.13210]

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Mocroft A.;Miro J. M.;Wandeler G.;Llibre J. M.;Boyd A.;van Bremen K.;Beniowski M.;Mikhalik J.;Cavassini M.;Maltez F.;Duvivier C.;Uberti Foppa C.;Knysz B.;Bakowska E.;Kuzovatova E.;Domingo P.;Zagalo A.;Viard J. -P.;Degen O.;Milinkovic A.;Benfield T.;Peters L.;Harxhi A.;Losso M.;Kundro M.;Schmied B.;Zangerle R.;Karpov I.;Vassilenko A.;Mitsura V. M.;Paduto D.;Clumeck N.;De Wit S.;Delforge M.;Florence E.;Vandekerckhove L.;Hadziosmanovic V.;Begovac J.;Machala L.;Sedlacek D.;Kronborg G.;Gerstoft J.;Katzenstein T.;Pedersen C.;Johansen I. S.;Ostergaard L.;Wiese L.;Moller N. F.;Nielsen L. N.;Zilmer K.;Smidt J.;Aho I.;Lacombe K.;Pradier C.;Fontas E.;Rockstroh J.;Behrens G.;Hoffmann C.;Stellbrink H. J.;Stefan C.;Bogner J.;Fatkenheuer G.;Chkhartishvili N.;Sambatakou H.;Adamis G.;Paissios N.;Szlavik J.;Gottfredsson M.;Devitt E.;Tau L.;Turner D.;Burke M.;Shahar E.;Wattad L. M.;Elinav H.;Haouzi M.;Elbirt D.;D'Arminio Monforte A.;Esposito R.;Mazeu I.;Mussini C.;Mazzotta F.;Gabbuti A.;Lazzarin A.;Castagna A.;Gianotti N.;Galli M.;Ridolfo A.;Uzdaviniene V.;Matulionyte R.;Staub T.;Hemmer R.;Dragas S.;Stevanovic M.;vd Valk M.;Trajanovska J.;Reikvam D. H.;Maeland A.;Bruun J.;Szetela B.;Inglot M.;Flisiak R.;Grzeszczuk A.;Parczewski M.;Maciejewska K.;Aksak-Was B.;Mularska E.;Jablonowska E.;Kamerys J.;Wojcik K.;Mozer-Lisewska I.;Rozplochowski B.;Mansinho K.;Radoi R.;Oprea C.;Gusev D.;Trofimova T.;Khromova I.;Borodulina E.;Ranin J.;Tomazic J.;Miro J. M.;Laguno M.;Martinez E.;Garcia F.;Blanco J. L.;Martinez-Rebollar M.;Mallolas J.;Callau P.;Rojas J.;Inciarta A.;Moreno S.;del Campo S.;Clotet B.;Jou A.;Paredes R.;Puig J.;Santos J. R.;Gutierrez M.;Mateo G.;Sambeat M. A.;Laporte J. M.;Svedhem V.;Thalme A.;Sonnerborg A.;Brannstrom J.;Flamholc L.;Kusejko K.;Braun D.;Calmy A.;Furrer H.;Battegay M.;Schmid P.;Kuznetsova A.;Sluzhynska M.;Johnson A. M.;Simons E.;Edwards S.;Phillips A.;Johnson M. A.;Orkin C.;Winston A.;Clarke A.;Leen C.;Karpov I.;Losso M.;Lundgren J.;Rockstroh J.;Aho I.;Rasmussen L. D.;Svedhem V.;Pradier C.;Chkhartishvili N.;Matulionyte R.;Oprea C.;Kowalska J. D.;Begovac J.;Miro J. M.;Guaraldi G.;Paredes R.;Paredes R.;Larsen J. F.;Bojesen A.;Neesgaard B.;Jaschinski N.;Fursa O.;Sather M.;Raben D.;Hansen E. V.;Kristensen D.;Fischer A. H.;Jensen S. K.;Elsing T. W.;Phillips A.;Reekie J.;Cozzi-Lepri A.;Amele S.;Pelchen-Matthews A.;Roen A.;Tusch E. S.;Bannister W.

2021

Abstract

Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94–8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47–12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00–1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00–1.89) and NHL (aIRR 2.57; 95% CI 1.16–5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.

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	Anno di pubblicazione
	
				2021
			
	Rivista
	
				HIV MEDICINE
			
	N° del Volume
	
				23
			
	Fascicolo
	
				6
			
	Pagina iniziale
	
				585
			
	Pagina finale
	
				598
			
	Codice DOI
	
				https://dx.doi.org/10.1111/hiv.13210
			
	Codice WoS
	
				WOS:000728470000001
			
	Codice Scopus
	
				2-s2.0-85120965873
			
	Citazione
	
				The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study / Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.; Uberti Foppa, C.; Knysz, B.; Bakowska, E.; Kuzovatova, E.; Domingo, P.; Zagalo, A.; Viard, J. -P.; Degen, O.; Milinkovic, A.; Benfield, T.; Peters, L.; Harxhi, A.; Losso, M.; Kundro, M.; Schmied, B.; Zangerle, R.; Karpov, I.; Vassilenko, A.; Mitsura, V. M.; Paduto, D.; Clumeck, N.; De Wit, S.; Delforge, M.; Florence, E.; Vandekerckhove, L.; Hadziosmanovic, V.; Begovac, J.; Machala, L.; Sedlacek, D.; Kronborg, G.; Gerstoft, J.; Katzenstein, T.; Pedersen, C.; Johansen, I. S.; Ostergaard, L.; Wiese, L.; Moller, N. F.; Nielsen, L. N.; Zilmer, K.; Smidt, J.; Aho, I.; Lacombe, K.; Pradier, C.; Fontas, E.; Rockstroh, J.; Behrens, G.; Hoffmann, C.; Stellbrink, H. J.; Stefan, C.; Bogner, J.; Fatkenheuer, G.; Chkhartishvili, N.; Sambatakou, H.; Adamis, G.; Paissios, N.; Szlavik, J.; Gottfredsson, M.; Devitt, E.; Tau, L.; Turner, D.; Burke, M.; Shahar, E.; Wattad, L. M.; Elinav, H.; Haouzi, M.; Elbirt, D.; D'Arminio Monforte, A.; Esposito, R.; Mazeu, I.; Mussini, C.; Mazzotta, F.; Gabbuti, A.; Lazzarin, A.; Castagna, A.; Gianotti, N.; Galli, M.; Ridolfo, A.; Uzdaviniene, V.; Matulionyte, R.; Staub, T.; Hemmer, R.; Dragas, S.; Stevanovic, M.; vd Valk, M.; Trajanovska, J.; Reikvam, D. H.; Maeland, A.; Bruun, J.; Szetela, B.; Inglot, M.; Flisiak, R.; Grzeszczuk, A.; Parczewski, M.; Maciejewska, K.; Aksak-Was, B.; Mularska, E.; Jablonowska, E.; Kamerys, J.; Wojcik, K.; Mozer-Lisewska, I.; Rozplochowski, B.; Mansinho, K.; Radoi, R.; Oprea, C.; Gusev, D.; Trofimova, T.; Khromova, I.; Borodulina, E.; Ranin, J.; Tomazic, J.; Miro, J. M.; Laguno, M.; Martinez, E.; Garcia, F.; Blanco, J. L.; Martinez-Rebollar, M.; Mallolas, J.; Callau, P.; Rojas, J.; Inciarta, A.; Moreno, S.; del Campo, S.; Clotet, B.; Jou, A.; Paredes, R.; Puig, J.; Santos, J. R.; Gutierrez, M.; Mateo, G.; Sambeat, M. A.; Laporte, J. M.; Svedhem, V.; Thalme, A.; Sonnerborg, A.; Brannstrom, J.; Flamholc, L.; Kusejko, K.; Braun, D.; Calmy, A.; Furrer, H.; Battegay, M.; Schmid, P.; Kuznetsova, A.; Sluzhynska, M.; Johnson, A. M.; Simons, E.; Edwards, S.; Phillips, A.; Johnson, M. A.; Orkin, C.; Winston, A.; Clarke, A.; Leen, C.; Karpov, I.; Losso, M.; Lundgren, J.; Rockstroh, J.; Aho, I.; Rasmussen, L. D.; Svedhem, V.; Pradier, C.; Chkhartishvili, N.; Matulionyte, R.; Oprea, C.; Kowalska, J. D.; Begovac, J.; Miro, J. M.; Guaraldi, G.; Paredes, R.; Paredes, R.; Larsen, J. F.; Bojesen, A.; Neesgaard, B.; Jaschinski, N.; Fursa, O.; Sather, M.; Raben, D.; Hansen, E. V.; Kristensen, D.; Fischer, A. H.; Jensen, S. K.; Elsing, T. W.; Phillips, A.; Reekie, J.; Cozzi-Lepri, A.; Amele, S.; Pelchen-Matthews, A.; Roen, A.; Tusch, E. S.; Bannister, W.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:6(2021), pp. 585-598. [10.1111/hiv.13210]
			
	Tutti gli autori
	
						Mocroft, A.; Miro, J. M.; Wandeler, G.; Llibre, J. M.; Boyd, A.; van Bremen, K.; Beniowski, M.; Mikhalik, J.; Cavassini, M.; Maltez, F.; Duvivier, C.;...espandi
						
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