This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and D-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle stimulating hormone (FSH) and DCI is an aromatase inhibitor. These activities allow a treatment for polycystic ovary syndrome (PCOS) to be defined based on the combined administration of MI and DCI, where the best MI:DCI ratio is 40:1. In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).
The importance of myo-inositol and D-chiro-inositol to support fertility and reproduction / Facchinetti, F.; Dewailly, D.; Soulage, C. O.; Unfer, V.; Marialuisa, A.; Cesare, A.; Daniele, B.; Salvatore, B.; Arturo, B.; Salome, B. E. M.; Mariano, B.; Tonino, C.; Pietro, C.; Shiao-Yng, C.; Yu, C. T. T.; Copp Andrew, J.; D'Anna, R.; Di Lorenzo, C.; Evanthia, D. -K.; Simona, D.; Greene Nicholas, D.; Imelda, H. M.; Moshe, H.; Zdravko, K.; Kandaraki Eleni, A.; Simone, L. A.; Giovanni, M.; Mario, M. O.; Nestler John, E.; Maurizio, N.; Cenk, O. A.; Olga, P.; Lali, P.; Giuseppina, P.; Nikos, P.; Roseff Scott, J.; Annarita, S.; Hebe, V. -L. M.; Ivana, V.; Artur, W.. - In: MT MÉDECINE DE LA REPRODUCTION. - ISSN 1774-640X. - 23:3(2021), pp. 213-221. [10.1684/mte.2021.0855]
The importance of myo-inositol and D-chiro-inositol to support fertility and reproduction
Facchinetti F.;
2021
Abstract
This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and D-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle stimulating hormone (FSH) and DCI is an aromatase inhibitor. These activities allow a treatment for polycystic ovary syndrome (PCOS) to be defined based on the combined administration of MI and DCI, where the best MI:DCI ratio is 40:1. In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).
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