Rituximab for people with multiple sclerosis

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The main objective is to assess the benefits and harms of rituximab compared to placebo or another DMT for people with multiple sclerosis. Specific comparisons include:. rituximab compared with placebo or other DMTs as first choice treatment for relapsing forms of MS; rituximab when switching from another DMT compared with placebo or other DMTs for relapsing forms of MS; rituximab compared with placebo or other DMTs as first choice treatment for progressive forms of MS; and rituximab when switching from another DMT compared with placebo or other DMTs for progressive forms of MS.