BACKGROUND AND AIM: Acrylamide is a probable carcinogen in humans. The main source of exposure to acrylamide in the general population is through diet. We performed a systematic literature review and dose-response meta-analysis of epidemiological studies evaluating the associations between dietary intake and specific subtypes of cancers. METHODS: A systematic literature search following PRISMA guidelines was conducted using Pubmed, Scopus and Web of Science until October 2020. Eligible studies included adults,assessment of dietary acrylamide (μg/day), risk estimates for increasing exposure to acrylamide, and cancer incidence. Quality of papers was assessed using the NIH’s Quality Assessment Tools for Observational Cohort and Case-Control Studies. We employed random-effects models comparing the highest versus the lowest intake of acrylamide and using the one-stage approach for dose-response meta-analysis. RESULTS:Out of 835 studies screened 28 studies were eligible for this meta-analysis. A total of 1 109 365 (mean age 60 years, range 45-70 years) participants were included, of which 61957 developed cancer. The mean follow-up period was 15.1 years (range 7.3-33.9). Mean estimated dose of acrylamide intake across studies was 22.6 µg/day. Pooled HR showed that high intake of acrylamide (35 µg/day) vs low intake (10 µg/day) was associated with increased risk of hematological malignances (summary HR: 1.4 95%CI:1.03-1.23). Dose-response meta-analysis showed evidence of linear association. No clear associations were noted between high intake of acrylamide (vs low) and esophageal, stomach, pancreatic, lung, renal, bladder-urothelial, and prostate cancers. Similar results were observed in the smoking stratification analysis CONCLUSIONS:From this dose-response meta-analysis of epidemiological studies investigating the association between dietary intake of acrylamide and specific subtypes of cancer, high intake of acrylamide was noted to be associated with increased risk of hematological malignancies. Further studies based on human biomonitoring data are needed to clarify the relationship of dietary acrylamide and cancers in humans. KEYWORDS: acrylamide, dietary exposure, neoplasms, epidemiological studies, Systematic Review

Dietary acrylamide and risk of specific subtypes of cancer: a dose response meta-analysis of epidemiological studies / Filippini, Tommaso; Halldorsson, Thorhallur I.; Capitão, Carolina; Martins, Raquel; Vinceti, Marco; Santos, Osvaldo; Virgolino, Ana; Laguzzi, Federica. - In: ENVIRONMENTAL HEALTH PERSPECTIVES. SUPPLEMENTS. - ISSN 1078-0475. - 2021:1(2021), pp. 525-525. (Intervento presentato al convegno 33rd Annual Conference of the International Society for Environmental Epidemiology. Promoting Environmental Health and Equity in a Shifting Climate tenutosi a Webinar nel 23-26 August 2021) [10.1289/isee.2021.P-474].

Dietary acrylamide and risk of specific subtypes of cancer: a dose response meta-analysis of epidemiological studies

Filippini, Tommaso;Vinceti, Marco;
2021

Abstract

BACKGROUND AND AIM: Acrylamide is a probable carcinogen in humans. The main source of exposure to acrylamide in the general population is through diet. We performed a systematic literature review and dose-response meta-analysis of epidemiological studies evaluating the associations between dietary intake and specific subtypes of cancers. METHODS: A systematic literature search following PRISMA guidelines was conducted using Pubmed, Scopus and Web of Science until October 2020. Eligible studies included adults,assessment of dietary acrylamide (μg/day), risk estimates for increasing exposure to acrylamide, and cancer incidence. Quality of papers was assessed using the NIH’s Quality Assessment Tools for Observational Cohort and Case-Control Studies. We employed random-effects models comparing the highest versus the lowest intake of acrylamide and using the one-stage approach for dose-response meta-analysis. RESULTS:Out of 835 studies screened 28 studies were eligible for this meta-analysis. A total of 1 109 365 (mean age 60 years, range 45-70 years) participants were included, of which 61957 developed cancer. The mean follow-up period was 15.1 years (range 7.3-33.9). Mean estimated dose of acrylamide intake across studies was 22.6 µg/day. Pooled HR showed that high intake of acrylamide (35 µg/day) vs low intake (10 µg/day) was associated with increased risk of hematological malignances (summary HR: 1.4 95%CI:1.03-1.23). Dose-response meta-analysis showed evidence of linear association. No clear associations were noted between high intake of acrylamide (vs low) and esophageal, stomach, pancreatic, lung, renal, bladder-urothelial, and prostate cancers. Similar results were observed in the smoking stratification analysis CONCLUSIONS:From this dose-response meta-analysis of epidemiological studies investigating the association between dietary intake of acrylamide and specific subtypes of cancer, high intake of acrylamide was noted to be associated with increased risk of hematological malignancies. Further studies based on human biomonitoring data are needed to clarify the relationship of dietary acrylamide and cancers in humans. KEYWORDS: acrylamide, dietary exposure, neoplasms, epidemiological studies, Systematic Review
2021
2021
525
525
Filippini, Tommaso; Halldorsson, Thorhallur I.; Capitão, Carolina; Martins, Raquel; Vinceti, Marco; Santos, Osvaldo; Virgolino, Ana; Laguzzi, Federica...espandi
Dietary acrylamide and risk of specific subtypes of cancer: a dose response meta-analysis of epidemiological studies / Filippini, Tommaso; Halldorsson, Thorhallur I.; Capitão, Carolina; Martins, Raquel; Vinceti, Marco; Santos, Osvaldo; Virgolino, Ana; Laguzzi, Federica. - In: ENVIRONMENTAL HEALTH PERSPECTIVES. SUPPLEMENTS. - ISSN 1078-0475. - 2021:1(2021), pp. 525-525. (Intervento presentato al convegno 33rd Annual Conference of the International Society for Environmental Epidemiology. Promoting Environmental Health and Equity in a Shifting Climate tenutosi a Webinar nel 23-26 August 2021) [10.1289/isee.2021.P-474].
File in questo prodotto:
File Dimensione Formato  
abs_ISEE2021_Laguzzi.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 527.48 kB
Formato Adobe PDF
527.48 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1274544
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact