This systematic review with meta-analysis aimed to assess the effect of diffuse liver diseases (DLD) on the risk of synchronous (S-) or metachronous (M-) liver metastases (LMs) in patients with solid neoplasms. Relevant databases were searched for systematic reviews and cross-sectional or cohort studies published since 1990 comparing the risk of LMs in patients with and without DLD (steatosis, viral hepatitis, cirrhosis, fibrosis) in non-liver solid cancer patients. Outcomes were prevalence of S-LMs, cumulative risk of M-LMs and LM-free survival. Risk of bias (ROB) was assessed using the Newcastle-Ottawa Scale. We report the pooled relative risks (RR) for S-LMs and hazard ratios (HR) for M-LMs. Subgroup analyses included DLD, primary site and continent. Nineteen studies were included (n = 37,591 patients), the majority on colorectal cancer. ROB appraisal results were mixed. Patients with DLD had a lower risk of S-LMs (RR 0.50, 95% CI 0.34–0.76), with a higher effect for cirrhosis and a slightly higher risk of M-LMs (HR 1.11 95% CI, 1.03–1.19), despite a lower risk of M-LMs in patients with vs without viral hepatitis (HR 0.57, 95% CI 0.40–0.82). There may have been a publication bias in favor of studies reporting a lower risk for patients with DLD. DLD are protective against S-LMs and slightly protective against M-LMs for viral hepatitis only.

The effect of diffuse liver diseases on the occurrence of liver metastases in cancer patients: A systematic review and meta-analysis / Monelli, F.; Besutti, G.; Djuric, O.; Bonvicini, L.; Fari, R.; Bonfatti, S.; Ligabue, G.; Bassi, M. C.; Damato, A.; Bonelli, C.; Pinto, C.; Pattacini, P.; Rossi, P. G.. - In: CANCERS. - ISSN 2072-6694. - 13:9(2021), pp. 2246-2250. [10.3390/cancers13092246]

The effect of diffuse liver diseases on the occurrence of liver metastases in cancer patients: A systematic review and meta-analysis

Monelli F.;Besutti G.;Bonvicini L.;Bonfatti S.;Ligabue G.;Bassi M. C.;Damato A.;Pinto C.;
2021

Abstract

This systematic review with meta-analysis aimed to assess the effect of diffuse liver diseases (DLD) on the risk of synchronous (S-) or metachronous (M-) liver metastases (LMs) in patients with solid neoplasms. Relevant databases were searched for systematic reviews and cross-sectional or cohort studies published since 1990 comparing the risk of LMs in patients with and without DLD (steatosis, viral hepatitis, cirrhosis, fibrosis) in non-liver solid cancer patients. Outcomes were prevalence of S-LMs, cumulative risk of M-LMs and LM-free survival. Risk of bias (ROB) was assessed using the Newcastle-Ottawa Scale. We report the pooled relative risks (RR) for S-LMs and hazard ratios (HR) for M-LMs. Subgroup analyses included DLD, primary site and continent. Nineteen studies were included (n = 37,591 patients), the majority on colorectal cancer. ROB appraisal results were mixed. Patients with DLD had a lower risk of S-LMs (RR 0.50, 95% CI 0.34–0.76), with a higher effect for cirrhosis and a slightly higher risk of M-LMs (HR 1.11 95% CI, 1.03–1.19), despite a lower risk of M-LMs in patients with vs without viral hepatitis (HR 0.57, 95% CI 0.40–0.82). There may have been a publication bias in favor of studies reporting a lower risk for patients with DLD. DLD are protective against S-LMs and slightly protective against M-LMs for viral hepatitis only.
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The effect of diffuse liver diseases on the occurrence of liver metastases in cancer patients: A systematic review and meta-analysis / Monelli, F.; Besutti, G.; Djuric, O.; Bonvicini, L.; Fari, R.; Bonfatti, S.; Ligabue, G.; Bassi, M. C.; Damato, A.; Bonelli, C.; Pinto, C.; Pattacini, P.; Rossi, P. G.. - In: CANCERS. - ISSN 2072-6694. - 13:9(2021), pp. 2246-2250. [10.3390/cancers13092246]
Monelli, F.; Besutti, G.; Djuric, O.; Bonvicini, L.; Fari, R.; Bonfatti, S.; Ligabue, G.; Bassi, M. C.; Damato, A.; Bonelli, C.; Pinto, C.; Pattacini, P.; Rossi, P. G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1271417
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