The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency. © 2002 Elsevier Science Ltd. All rights reserved.
Synthesis and antiplatelet activity of gemfibrozil chiral analogues / Ammazzalorso, A.; Amoroso, R.; Baraldi, M.; Bettoni, G.; Braghiroli, D.; De Filippis, B.; Duranti, A.; Moretti, M.; Tortorella, P.; Tricca, M. L.; Vezzalini, F.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 12:5(2002), pp. 817-821. [10.1016/S0960-894X(02)00021-5]
Synthesis and antiplatelet activity of gemfibrozil chiral analogues
Braghiroli D.;Vezzalini F.
2002
Abstract
The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency. © 2002 Elsevier Science Ltd. All rights reserved.
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