: Background: Kidney transplant (KT) recipients with COVID-19 are at high risk of poor outcomes due to the high burden of comorbidities and immunosuppression. The effects of immunosuppressive therapy (IST) reduction are unclear in patients with COVID-19. Methods: A retrospective study on 45 KT recipients followed at the University Hospital of Modena (Italy) who tested positive for COVID-19 by RT-PCR analysis. Results: The median age was 56.1 years (interquartile range,[IQR] 47.3-61.1), with a predominance of males (64.4%). Kidney transplantation vintage was 10.1 (2.7-16) years, and 55.6 % of patients were on triple IST before COVID-19. Early immunosuppression minimization occurred in 27 (60%) patients (reduced-dose IST group) and included antimetabolite (88.8%) and calcineurin inhibitor withdrawal (22.2%). After SARS-CoV-2 infection, 88.9% of patients became symptomatic and 42.2% required hospitalization. One patient experienced irreversible graft failure. There were no differences in serum creatinine level and proteinuria in non-hospitalized patients before and post-COVID-19, whereas hospitalized patients experienced better kidney function after hospital discharge (P=0.019). Overall mortality was 17.8%. without differences between full- and reduced-dose IST. Risk factors for death were age (odds ratio [OR]: 1.19; 95%CI: 1.01-1.39), and duration of kidney transplant (OR: 1.17; 95%CI: 1.01-1.35). One KT recipient developed IgA glomerulonephritis and two ones experienced symptomatic COVID-19 after primary infection and SARS-CoV-2 mRNA vaccine, respectively. Conclusions: Despite the reduction of immunosuppression, COVID-19 affected the survival of KT recipients. Age of patients and time elapsed from kidney transplantation were independent predictors of death . Early kidney function was favorable in most survivors after COVID-19.

Immunosuppressive therapy reduction and early post-infection graft function in kidney transplant recipients with COVID-19 / Alfano, Gaetano; Damiano, Francesca; Fontana, Francesco; Ferri, Camilla; Melluso, Andrea; Montani, Martina; Morisi, Niccolò; Tei, Lorenzo; Plessi, Jessica; Giovanella, Silvia; Ligabue, Giulia; Mori, Giacomo; Guaraldi, Giovanni; Magistroni, Riccardo; Cappelli, Gianni; Donati, Gabriele. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 1724-5990. - 38:6(2021), pp. 1-10.

Immunosuppressive therapy reduction and early post-infection graft function in kidney transplant recipients with COVID-19

Alfano, Gaetano;Damiano, Francesca;Fontana, Francesco;Morisi, Niccolò;Tei, Lorenzo;Plessi, Jessica;Giovanella, Silvia;Ligabue, Giulia;Mori, Giacomo;Guaraldi, Giovanni;Magistroni, Riccardo;Cappelli, Gianni;Donati, Gabriele
2021

Abstract

: Background: Kidney transplant (KT) recipients with COVID-19 are at high risk of poor outcomes due to the high burden of comorbidities and immunosuppression. The effects of immunosuppressive therapy (IST) reduction are unclear in patients with COVID-19. Methods: A retrospective study on 45 KT recipients followed at the University Hospital of Modena (Italy) who tested positive for COVID-19 by RT-PCR analysis. Results: The median age was 56.1 years (interquartile range,[IQR] 47.3-61.1), with a predominance of males (64.4%). Kidney transplantation vintage was 10.1 (2.7-16) years, and 55.6 % of patients were on triple IST before COVID-19. Early immunosuppression minimization occurred in 27 (60%) patients (reduced-dose IST group) and included antimetabolite (88.8%) and calcineurin inhibitor withdrawal (22.2%). After SARS-CoV-2 infection, 88.9% of patients became symptomatic and 42.2% required hospitalization. One patient experienced irreversible graft failure. There were no differences in serum creatinine level and proteinuria in non-hospitalized patients before and post-COVID-19, whereas hospitalized patients experienced better kidney function after hospital discharge (P=0.019). Overall mortality was 17.8%. without differences between full- and reduced-dose IST. Risk factors for death were age (odds ratio [OR]: 1.19; 95%CI: 1.01-1.39), and duration of kidney transplant (OR: 1.17; 95%CI: 1.01-1.35). One KT recipient developed IgA glomerulonephritis and two ones experienced symptomatic COVID-19 after primary infection and SARS-CoV-2 mRNA vaccine, respectively. Conclusions: Despite the reduction of immunosuppression, COVID-19 affected the survival of KT recipients. Age of patients and time elapsed from kidney transplantation were independent predictors of death . Early kidney function was favorable in most survivors after COVID-19.
38
6
1
10
Immunosuppressive therapy reduction and early post-infection graft function in kidney transplant recipients with COVID-19 / Alfano, Gaetano; Damiano, Francesca; Fontana, Francesco; Ferri, Camilla; Melluso, Andrea; Montani, Martina; Morisi, Niccolò; Tei, Lorenzo; Plessi, Jessica; Giovanella, Silvia; Ligabue, Giulia; Mori, Giacomo; Guaraldi, Giovanni; Magistroni, Riccardo; Cappelli, Gianni; Donati, Gabriele. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 1724-5990. - 38:6(2021), pp. 1-10.
Alfano, Gaetano; Damiano, Francesca; Fontana, Francesco; Ferri, Camilla; Melluso, Andrea; Montani, Martina; Morisi, Niccolò; Tei, Lorenzo; Plessi, Jessica; Giovanella, Silvia; Ligabue, Giulia; Mori, Giacomo; Guaraldi, Giovanni; Magistroni, Riccardo; Cappelli, Gianni; Donati, Gabriele
File in questo prodotto:
File Dimensione Formato  
Alfano- Immunosuppressive therapy.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 512.33 kB
Formato Adobe PDF
512.33 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1258701
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact