An increasing number of pollutants with endocrine disrupting potential are accumulating in the environment, increasing the exposure risk for humans. Several of them are known or suspected to interfere with endocrine signals, impairing reproductive functions. Follicle-stimulating hormone (FSH) is a glycoprotein playing an essential role in supporting antral follicle maturation and may be a target of disrupting chemicals (EDs) likely impacting female fertility. EDs may interfere with FSH-mediated signals at different levels, since they may modulate the mRNA or protein levels of both the hormone and its receptor (FSHR), perturb the functioning of partner membrane molecules, modify intracellular signal transduction pathways and gene expression. In vitro studies and animal models provided results helpful to understand ED modes of action and suggest that they could effectively play a role as molecules interfering with the female reproductive system. However, most of these data are potentially subjected to experimental limitations and need to be confirmed by long-term observations in human.

Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth / Roy, N.; Mascolo, E.; Lazzaretti, C.; Paradiso, E.; D'Alessandro, S.; Zareba, K.; Simoni, M.; Casarini, L.. - In: FRONTIERS IN ENDOCRINOLOGY. - ISSN 1664-2392. - 12:(2021), pp. 791763-791774. [10.3389/fendo.2021.791763]

Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth

Roy N.;Mascolo E.;Lazzaretti C.;Paradiso E.;D'Alessandro S.;Simoni M.;Casarini L.
2021

Abstract

An increasing number of pollutants with endocrine disrupting potential are accumulating in the environment, increasing the exposure risk for humans. Several of them are known or suspected to interfere with endocrine signals, impairing reproductive functions. Follicle-stimulating hormone (FSH) is a glycoprotein playing an essential role in supporting antral follicle maturation and may be a target of disrupting chemicals (EDs) likely impacting female fertility. EDs may interfere with FSH-mediated signals at different levels, since they may modulate the mRNA or protein levels of both the hormone and its receptor (FSHR), perturb the functioning of partner membrane molecules, modify intracellular signal transduction pathways and gene expression. In vitro studies and animal models provided results helpful to understand ED modes of action and suggest that they could effectively play a role as molecules interfering with the female reproductive system. However, most of these data are potentially subjected to experimental limitations and need to be confirmed by long-term observations in human.
12
791763
791774
Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth / Roy, N.; Mascolo, E.; Lazzaretti, C.; Paradiso, E.; D'Alessandro, S.; Zareba, K.; Simoni, M.; Casarini, L.. - In: FRONTIERS IN ENDOCRINOLOGY. - ISSN 1664-2392. - 12:(2021), pp. 791763-791774. [10.3389/fendo.2021.791763]
Roy, N.; Mascolo, E.; Lazzaretti, C.; Paradiso, E.; D'Alessandro, S.; Zareba, K.; Simoni, M.; Casarini, L.
File in questo prodotto:
File Dimensione Formato  
2021 Roy et al - Frontiers in Endocrinology.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 5.33 MB
Formato Adobe PDF
5.33 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1258598
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 1
social impact