Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has been evaluated as a possible novel treatment for SE. Notwithstanding the positive results obtained in the animal models of SE, the use of allopregnanolone for the treatment of benzodiazepine-resistant SE in humans resulted in controversial findings. Here, we summarize the main preclinical and clinical evidence about the effects of neurosteroids on SE to provide a possible pathophysiological background for their rational use.

Neurosteroids and Status Epilepticus / Gol, Mohammad; Lucchi, Chiara; Biagini, Giuseppe. - In: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. - ISSN 2451-9650. - 22:(2022), pp. 1-7. [10.1016/j.coemr.2021.100311]

Neurosteroids and Status Epilepticus

Gol, Mohammad;Lucchi, Chiara;Biagini, Giuseppe
2022

Abstract

Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has been evaluated as a possible novel treatment for SE. Notwithstanding the positive results obtained in the animal models of SE, the use of allopregnanolone for the treatment of benzodiazepine-resistant SE in humans resulted in controversial findings. Here, we summarize the main preclinical and clinical evidence about the effects of neurosteroids on SE to provide a possible pathophysiological background for their rational use.
11-dic-2021
22
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7
Neurosteroids and Status Epilepticus / Gol, Mohammad; Lucchi, Chiara; Biagini, Giuseppe. - In: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. - ISSN 2451-9650. - 22:(2022), pp. 1-7. [10.1016/j.coemr.2021.100311]
Gol, Mohammad; Lucchi, Chiara; Biagini, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1257417
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