Background: Surgical resection is a first-line curative option for hepatocellular carcinoma, but its role is still unclear in elderly patients. The aim of our study was to compare short- and long-term outcomes of laparoscopic and open liver resection in elderly patients with hepatocellular carcinoma. Methods: The study included 665 consecutive hepatocellular carcinoma liver resection cases in patients with ≥70 years of age treated in eight European hospital centres. Patients were divided into laparoscopic and open liver resection groups. Perioperative and long-term outcomes were compared between these groups. Results: After a 1:1 propensity score matching, 219 patients were included in each group. Clavien-Dindo grades III/IV (6 vs. 20%, p = 0.04) were lower in the laparoscopic than in the open matched group. Hospital stay was shorter in the laparoscopic than in the open matched group (5 vs. 7 days, p < 0.001). There were no significant differences between laparoscopic and open groups regarding overall survival and disease-free survival at 1-, 3- and 5- year periods. Conclusion: Laparoscopic liver resection for hepatocellular carcinoma is associated with good short-term outcomes in patients with ≥70 years of age compared to open liver resection. Laparoscopic liver resection is safe and feasible in elderly patients with hepatocellular carcinoma.

Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: a propensity score matching analysis / Delvecchio, A.; Conticchio, M.; Riccelli, U.; Ferraro, V.; Ratti, F.; Gelli, M.; Anelli, F. M.; Laurent, A.; Vitali, G. C.; Magistri, P.; Assirati, G.; Felli, E.; Wakabayashi, T.; Pessaux, P.; Piardi, T.; Di Benedetto, F.; De'Angelis, N.; Briceno-Delgado, J.; Adam, R.; Cherqui, D.; Aldrighetti, L.; Memeo, R.. - In: HPB. - ISSN 1365-182X. - 24:6(2022), pp. 933-941. [10.1016/j.hpb.2021.10.024]

Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: a propensity score matching analysis

Magistri P.;Assirati G.;Di Benedetto F.;
2022

Abstract

Background: Surgical resection is a first-line curative option for hepatocellular carcinoma, but its role is still unclear in elderly patients. The aim of our study was to compare short- and long-term outcomes of laparoscopic and open liver resection in elderly patients with hepatocellular carcinoma. Methods: The study included 665 consecutive hepatocellular carcinoma liver resection cases in patients with ≥70 years of age treated in eight European hospital centres. Patients were divided into laparoscopic and open liver resection groups. Perioperative and long-term outcomes were compared between these groups. Results: After a 1:1 propensity score matching, 219 patients were included in each group. Clavien-Dindo grades III/IV (6 vs. 20%, p = 0.04) were lower in the laparoscopic than in the open matched group. Hospital stay was shorter in the laparoscopic than in the open matched group (5 vs. 7 days, p < 0.001). There were no significant differences between laparoscopic and open groups regarding overall survival and disease-free survival at 1-, 3- and 5- year periods. Conclusion: Laparoscopic liver resection for hepatocellular carcinoma is associated with good short-term outcomes in patients with ≥70 years of age compared to open liver resection. Laparoscopic liver resection is safe and feasible in elderly patients with hepatocellular carcinoma.
2022
5-nov-2021
HPB
24
6
933
941
Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: a propensity score matching analysis / Delvecchio, A.; Conticchio, M.; Riccelli, U.; Ferraro, V.; Ratti, F.; Gelli, M.; Anelli, F. M.; Laurent, A.; Vitali, G. C.; Magistri, P.; Assirati, G.; Felli, E.; Wakabayashi, T.; Pessaux, P.; Piardi, T.; Di Benedetto, F.; De'Angelis, N.; Briceno-Delgado, J.; Adam, R.; Cherqui, D.; Aldrighetti, L.; Memeo, R.. - In: HPB. - ISSN 1365-182X. - 24:6(2022), pp. 933-941. [10.1016/j.hpb.2021.10.024]
Delvecchio, A.; Conticchio, M.; Riccelli, U.; Ferraro, V.; Ratti, F.; Gelli, M.; Anelli, F. M.; Laurent, A.; Vitali, G. C.; Magistri, P.; Assirati, G....espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1257316
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 10
social impact