Acute kidney injury (AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome (HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice.
Hepatorenal syndrome: Update on diagnosis and treatment / Baraldi, O; Valentini, C; Donati, G; Comai, G; Cuna, V; Capelli, I; Angelini, Ml; Moretti, Mi; Angeletti, A; Piscaglia, F; La Manna, G. - In: WORLD JOURNAL OF NEPHROLOGY. - ISSN 2220-6124. - 4:5(2015), pp. 511-520. [10.5527/wjn.v4.i5.511]
Hepatorenal syndrome: Update on diagnosis and treatment
Donati G;
2015
Abstract
Acute kidney injury (AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome (HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice.
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