Cardiovascular disease is the leading cause of mortality and morbidity in renal transplant recipients as well as the leading cause of death with a functioning graft. The high cardiovascular risk is attributable to the prolonged exposure to multiple traditional and nontraditional risk factors in the pretransplant and posttransplant period. Particular attention must be paid to cardiovascular screening of candidates for kidney transplantation. After a transplant, treatment and prevention strategies should be focused on the modifiable risk factors including smoking, dietary habits, physical activity, weight control, hypertension, and dyslipidemia. Further studies on these factors are needed to better define the pharmacological approaches (hypotensive or hypolipemic drugs) and therapeutic targets. In view of the role of immunosuppressive therapy in the onset or worsening of several risk factors, it is important to tailor the treatment approach and dosage to the cardiovascular risk profile of the individual patient.
Factors determining cardiovascular disease progression after kidney transplant / Scolari, Maria; LA MANNA, Gaetano; Cianciolo, Giuseppe; Cappuccilli, Maria; Lanci, Nicole; Donati, Gabriele; Persici, Elisa; Cuna, Vania; Feliciangeli, Giorgio; LIVIANO D'ARCANGELO, Giovanni; Mosconi, Giovanni; Stefoni, Sergio. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 0393-5590. - 26:(2009), pp. 30-43.
Factors determining cardiovascular disease progression after kidney transplant
SCOLARI, MARIA;DONATI, GABRIELE;
2009
Abstract
Cardiovascular disease is the leading cause of mortality and morbidity in renal transplant recipients as well as the leading cause of death with a functioning graft. The high cardiovascular risk is attributable to the prolonged exposure to multiple traditional and nontraditional risk factors in the pretransplant and posttransplant period. Particular attention must be paid to cardiovascular screening of candidates for kidney transplantation. After a transplant, treatment and prevention strategies should be focused on the modifiable risk factors including smoking, dietary habits, physical activity, weight control, hypertension, and dyslipidemia. Further studies on these factors are needed to better define the pharmacological approaches (hypotensive or hypolipemic drugs) and therapeutic targets. In view of the role of immunosuppressive therapy in the onset or worsening of several risk factors, it is important to tailor the treatment approach and dosage to the cardiovascular risk profile of the individual patient.File | Dimensione | Formato | |
---|---|---|---|
Scolari_GIN 2009.pdf
Accesso riservato
Dimensione
10.02 MB
Formato
Adobe PDF
|
10.02 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris