Background High mannose has previously associated with insulin resistance and cardiovascular disease (CVD). Our objective is to establish whether mannose is associated with anatomical evidence of coronary artery disease (CAD). Methods Plasma mannose concentrations were measured by liquid chromatography/tandem mass spectrometry in a discovery cohort (n = 513) and a validation cohort (n = 221) of carefully phenotyped individuals. In both cohorts CAD was quantitated using state-of-the-art imaging techniques (coronary computed coronary tomography angiography (CCTA), invasive coronary angiography and optical coherence tomography). Information on subsequent CVD events/death was collected. Associations of mannose with angiographic variables and biomarkers were tested using univariate and multivariate regression models. Survival analysis was performed using the Kaplan-Meier estimator. Results Mannose was related to indices of CAD and features of plaque vulnerability. In the discovery cohort, mannose was a marker of quantity and quality of CCTA-proven CAD and subjects with a mannose level in the top quartile had a significantly higher risk of CVD events/death (p = 3.6e-5). In the validation cohort, mannose was significantly associated with fibrous cap thickness < 65 μm (odds ratio = 1.32 per each 10 μmol/L mannose change [95% confidence interval, 1.05–1.65]) and was an independent predictor of death (hazard ratio for mannose≥vs < 84.6 μmol/L: 4.0(95%CI, 1.4–11.3), p = 0.006).

Mannose as a biomarker of coronary artery disease: Angiographic evidence and clinical significance / Modena, Maria Grazia; Ferrannini, Ele; Marx, Nikolaus; Andreini, Daniele; Campi, Beatrice; Saba, Alessandro; Gorini, Marco; Ferranni, Giulia; Milzi, Andrea; Magnoni, Marco; Maseri, Attilio; Maggioni, Aldo P.; Burgmaier on behalf of the CAPIRE investigators, Mathias. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 1874-1754. - 346:(2022), pp. 86-92. [10.1016/j.ijcard.2021.11.038]

Mannose as a biomarker of coronary artery disease: Angiographic evidence and clinical significance

Maria Grazia Modena
Membro del Collaboration Group
;
2022

Abstract

Background High mannose has previously associated with insulin resistance and cardiovascular disease (CVD). Our objective is to establish whether mannose is associated with anatomical evidence of coronary artery disease (CAD). Methods Plasma mannose concentrations were measured by liquid chromatography/tandem mass spectrometry in a discovery cohort (n = 513) and a validation cohort (n = 221) of carefully phenotyped individuals. In both cohorts CAD was quantitated using state-of-the-art imaging techniques (coronary computed coronary tomography angiography (CCTA), invasive coronary angiography and optical coherence tomography). Information on subsequent CVD events/death was collected. Associations of mannose with angiographic variables and biomarkers were tested using univariate and multivariate regression models. Survival analysis was performed using the Kaplan-Meier estimator. Results Mannose was related to indices of CAD and features of plaque vulnerability. In the discovery cohort, mannose was a marker of quantity and quality of CCTA-proven CAD and subjects with a mannose level in the top quartile had a significantly higher risk of CVD events/death (p = 3.6e-5). In the validation cohort, mannose was significantly associated with fibrous cap thickness < 65 μm (odds ratio = 1.32 per each 10 μmol/L mannose change [95% confidence interval, 1.05–1.65]) and was an independent predictor of death (hazard ratio for mannose≥vs < 84.6 μmol/L: 4.0(95%CI, 1.4–11.3), p = 0.006).
2022
18-nov-2021
346
86
92
Mannose as a biomarker of coronary artery disease: Angiographic evidence and clinical significance / Modena, Maria Grazia; Ferrannini, Ele; Marx, Nikolaus; Andreini, Daniele; Campi, Beatrice; Saba, Alessandro; Gorini, Marco; Ferranni, Giulia; Milzi, Andrea; Magnoni, Marco; Maseri, Attilio; Maggioni, Aldo P.; Burgmaier on behalf of the CAPIRE investigators, Mathias. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 1874-1754. - 346:(2022), pp. 86-92. [10.1016/j.ijcard.2021.11.038]
Modena, Maria Grazia; Ferrannini, Ele; Marx, Nikolaus; Andreini, Daniele; Campi, Beatrice; Saba, Alessandro; Gorini, Marco; Ferranni, Giulia; Milzi, Andrea; Magnoni, Marco; Maseri, Attilio; Maggioni, Aldo P.; Burgmaier on behalf of the CAPIRE investigators, Mathias
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1256060
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