Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to select those patients with a low risk of residual axillary disease after NAC, in whom axillary surgery could be minimized. Patients and methods: 1950 clinically node-positive BC patients from 11 Breast Units, treated by NAC and subsequent surgery, were included from 2005 to 2020. Patients were divided in two groups: those who achieved nodal pCR vs. those with residual nodal disease after NAC. The cohort was divided into training and validation set with a geographic separation criterion. The outcome was to identify independent predictors of axillary pathologic complete response (pCR). Results: Independent predictive factors associated to nodal pCR were axillary clinical complete response (cCR) after NAC (OR 3.11, p < 0.0001), ER-/HER2+ (OR 3.26, p < 0.0001) or ER+/HER2+ (OR 2.26, p = 0.0002) or ER-/HER2- (OR 1.89, p = 0.009) BC, breast cCR (OR 2.48, p < 0.0001), Ki67 > 14% (OR 0.52, p = 0.0005), and tumor grading G2 (OR 0.35, p = 0.002) or G3 (OR 0.29, p = 0.0003). The nomogram showed a sensitivity of 71% and a specificity of 73% (AUC 0.77, 95%CI 0.75–0.80). After external validation the accuracy of the nomogram was confirmed. Conclusion: The accuracy makes this freely-available, nomogram-based online tool useful to predict nodal pCR after NAC, translating the concept of tailored axillary surgery also in this setting of patients.

Development of a novel nomogram-based online tool to predict axillary status after neoadjuvant chemotherapy in cN+ breast cancer: A multicentre study on 1,950 patients / Corsi, F.; Albasini, S.; Sorrentino, L.; Armatura, G.; Carolla, C.; Chiappa, C.; Combi, F.; Curcio, A.; Della Valle, A.; Ferrari, G.; Gasparri, M. L.; Gentilini, O.; Ghilli, M.; Listorti, C.; Mancini, S.; Marinello, P.; Meani, F.; Mele, S.; Pertusati, A.; Roncella, M.; Rovera, F.; Sgarella, A.; Tazzioli, G.; Tognali, D.; Folli, S.. - In: THE BREAST. - ISSN 0960-9776. - 60:(2021), pp. 131-137. [10.1016/j.breast.2021.09.013]

Development of a novel nomogram-based online tool to predict axillary status after neoadjuvant chemotherapy in cN+ breast cancer: A multicentre study on 1,950 patients

Combi F.;Curcio A.;Mancini S.;Mele S.;Tazzioli G.;
2021-01-01

Abstract

Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to select those patients with a low risk of residual axillary disease after NAC, in whom axillary surgery could be minimized. Patients and methods: 1950 clinically node-positive BC patients from 11 Breast Units, treated by NAC and subsequent surgery, were included from 2005 to 2020. Patients were divided in two groups: those who achieved nodal pCR vs. those with residual nodal disease after NAC. The cohort was divided into training and validation set with a geographic separation criterion. The outcome was to identify independent predictors of axillary pathologic complete response (pCR). Results: Independent predictive factors associated to nodal pCR were axillary clinical complete response (cCR) after NAC (OR 3.11, p < 0.0001), ER-/HER2+ (OR 3.26, p < 0.0001) or ER+/HER2+ (OR 2.26, p = 0.0002) or ER-/HER2- (OR 1.89, p = 0.009) BC, breast cCR (OR 2.48, p < 0.0001), Ki67 > 14% (OR 0.52, p = 0.0005), and tumor grading G2 (OR 0.35, p = 0.002) or G3 (OR 0.29, p = 0.0003). The nomogram showed a sensitivity of 71% and a specificity of 73% (AUC 0.77, 95%CI 0.75–0.80). After external validation the accuracy of the nomogram was confirmed. Conclusion: The accuracy makes this freely-available, nomogram-based online tool useful to predict nodal pCR after NAC, translating the concept of tailored axillary surgery also in this setting of patients.
60
131
137
Development of a novel nomogram-based online tool to predict axillary status after neoadjuvant chemotherapy in cN+ breast cancer: A multicentre study on 1,950 patients / Corsi, F.; Albasini, S.; Sorrentino, L.; Armatura, G.; Carolla, C.; Chiappa, C.; Combi, F.; Curcio, A.; Della Valle, A.; Ferrari, G.; Gasparri, M. L.; Gentilini, O.; Ghilli, M.; Listorti, C.; Mancini, S.; Marinello, P.; Meani, F.; Mele, S.; Pertusati, A.; Roncella, M.; Rovera, F.; Sgarella, A.; Tazzioli, G.; Tognali, D.; Folli, S.. - In: THE BREAST. - ISSN 0960-9776. - 60:(2021), pp. 131-137. [10.1016/j.breast.2021.09.013]
Corsi, F.; Albasini, S.; Sorrentino, L.; Armatura, G.; Carolla, C.; Chiappa, C.; Combi, F.; Curcio, A.; Della Valle, A.; Ferrari, G.; Gasparri, M. L.; Gentilini, O.; Ghilli, M.; Listorti, C.; Mancini, S.; Marinello, P.; Meani, F.; Mele, S.; Pertusati, A.; Roncella, M.; Rovera, F.; Sgarella, A.; Tazzioli, G.; Tognali, D.; Folli, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1255764
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