The impact of donor age on the recurrence of hepatocellular carcinoma (HCC) after liver transplantation is still debated. Between 2002 and 2014, all patients transplanted for HCC in 2 European liver transplantation tertiary centres were retrospectively reviewed. Risk factors for HCC recurrence were assessed using competing risk analysis, and the impact of donor age < or ≥65 years and < or ≥80 years was specifically evaluated after propensity score matching. 728 patients transplanted with a median follow-up of 86 months were analysed. The 1-, 3- and 5-year recurrence rates were 4.9%, 10.7% and 13.9%, respectively. In multivariable analysis, recipient age (sHR: 0.96 [0.93; 0.98], P < 0.01), number of lesions (sHR: 1.05 [1.04; 1.06], P < 0.001), maximum size of the lesions (sHR: 1.37 [1.27; 1.48], P < 0.01), presence of a hepatocholangiocarcinoma (sHR: 6.47 [2.91; 14.38], P < 0.01) and microvascular invasion (sHR: 3.48 [2.42; 5.02], P < 0.01) were significantly associated with HCC recurrence. After propensity score matching, neither donor age ≥65 (P = 0.29) nor donor age ≥80 (P = 0.84) years increased the risk of HCC recurrence. In conclusion, donor age was not found to be a risk factor for HCC recurrence. Patients listed for HCC can receive a graft from an elderly donor without compromising the outcome.

Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: a retrospective two-centre analysis using competing risk analysis / Cusumano, C.; De Carlis, L.; Centonze, L.; Lesourd, R.; Levi Sandri, G. B.; Lauterio, A.; De Carlis, R.; Ferla, F.; Di Sandro, S.; Camus, C.; Jezequel, C.; Bardou-Jacquet, E.; Rayar, M.. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - 34:10(2021), pp. 1948-1958. [10.1111/tri.13950]

Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: a retrospective two-centre analysis using competing risk analysis

Di Sandro S.;
2021

Abstract

The impact of donor age on the recurrence of hepatocellular carcinoma (HCC) after liver transplantation is still debated. Between 2002 and 2014, all patients transplanted for HCC in 2 European liver transplantation tertiary centres were retrospectively reviewed. Risk factors for HCC recurrence were assessed using competing risk analysis, and the impact of donor age < or ≥65 years and < or ≥80 years was specifically evaluated after propensity score matching. 728 patients transplanted with a median follow-up of 86 months were analysed. The 1-, 3- and 5-year recurrence rates were 4.9%, 10.7% and 13.9%, respectively. In multivariable analysis, recipient age (sHR: 0.96 [0.93; 0.98], P < 0.01), number of lesions (sHR: 1.05 [1.04; 1.06], P < 0.001), maximum size of the lesions (sHR: 1.37 [1.27; 1.48], P < 0.01), presence of a hepatocholangiocarcinoma (sHR: 6.47 [2.91; 14.38], P < 0.01) and microvascular invasion (sHR: 3.48 [2.42; 5.02], P < 0.01) were significantly associated with HCC recurrence. After propensity score matching, neither donor age ≥65 (P = 0.29) nor donor age ≥80 (P = 0.84) years increased the risk of HCC recurrence. In conclusion, donor age was not found to be a risk factor for HCC recurrence. Patients listed for HCC can receive a graft from an elderly donor without compromising the outcome.
34
10
1948
1958
Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: a retrospective two-centre analysis using competing risk analysis / Cusumano, C.; De Carlis, L.; Centonze, L.; Lesourd, R.; Levi Sandri, G. B.; Lauterio, A.; De Carlis, R.; Ferla, F.; Di Sandro, S.; Camus, C.; Jezequel, C.; Bardou-Jacquet, E.; Rayar, M.. - In: TRANSPLANT INTERNATIONAL. - ISSN 0934-0874. - 34:10(2021), pp. 1948-1958. [10.1111/tri.13950]
Cusumano, C.; De Carlis, L.; Centonze, L.; Lesourd, R.; Levi Sandri, G. B.; Lauterio, A.; De Carlis, R.; Ferla, F.; Di Sandro, S.; Camus, C.; Jezequel, C.; Bardou-Jacquet, E.; Rayar, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1252837
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