This study compared the outcomes of cataract surgery with intraocular lens (IOL) implantation in patients with juvenile idiopathic arthritis (JIA)-associated chronic anterior uveitis treated with antimetabolite drugs and systemic corticosteroids (Non-Biological Group) versus patients treated with antimetabolites and biological drugs (Biological Group). A cohort of patients with cataract in JIA-associated uveitis undergoing phacoemulsification with IOL implantation was retrospectively evaluated. The main outcome was a change in corrected distance visual acuity (CDVA) in the two groups. Ocular and systemic complications were also recorded. The data were collected preoperatively and at 1, 12, and 48 months after surgery. Thirty-two eyes of 24 children were included: 10 eyes in the Non-Biological Group and 22 eyes in the Biological Group. The mean CDVA improved from 1.19 +/- 0.72 logMAR preoperatively to 0.98 +/- 0.97 logMAR at 48 months (p = 0.45) in the Non-Biological Group and from 1.55 +/- 0.91 logMAR preoperatively to 0.57 +/- 0.83 logMAR at 48 months (p = 0.001) in the Biological Group. The postoperative complications, including synechiae, cyclitic membrane, IOL explantation, glaucoma, and macular edema, were not statistically different between the two groups. An immunosuppressive treatment with biological drugs can improve the visual outcome after cataract surgery in patients with JIA-associated uveitis, but it does not significantly reduce postoperative ocular complications.

Cataract Surgery with Intraocular Lens Implantation in Juvenile Idiopathic Arthritis-Associated Uveitis: Outcomes in the Era of Biological Therapy / Bolletta, Elena; Coassin, Marco; Iannetta, Danilo; Mastrofilippo, Valentina; Aldigeri, Raffaella; Invernizzi, Alessandro; de Simone, Luca; Gozzi, Fabrizio; De Fanti, Alessandro; Cappella, Michela; Adani, Chantal; Neri, Alberto; Moramarco, Antonio; De Maria, Michele; Salvarani, Carlo; Fontana, Luigi; Cimino, Luca. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:11(2021), pp. 1-9. [10.3390/jcm10112437]

Cataract Surgery with Intraocular Lens Implantation in Juvenile Idiopathic Arthritis-Associated Uveitis: Outcomes in the Era of Biological Therapy

Salvarani, Carlo;Cimino, Luca
2021

Abstract

This study compared the outcomes of cataract surgery with intraocular lens (IOL) implantation in patients with juvenile idiopathic arthritis (JIA)-associated chronic anterior uveitis treated with antimetabolite drugs and systemic corticosteroids (Non-Biological Group) versus patients treated with antimetabolites and biological drugs (Biological Group). A cohort of patients with cataract in JIA-associated uveitis undergoing phacoemulsification with IOL implantation was retrospectively evaluated. The main outcome was a change in corrected distance visual acuity (CDVA) in the two groups. Ocular and systemic complications were also recorded. The data were collected preoperatively and at 1, 12, and 48 months after surgery. Thirty-two eyes of 24 children were included: 10 eyes in the Non-Biological Group and 22 eyes in the Biological Group. The mean CDVA improved from 1.19 +/- 0.72 logMAR preoperatively to 0.98 +/- 0.97 logMAR at 48 months (p = 0.45) in the Non-Biological Group and from 1.55 +/- 0.91 logMAR preoperatively to 0.57 +/- 0.83 logMAR at 48 months (p = 0.001) in the Biological Group. The postoperative complications, including synechiae, cyclitic membrane, IOL explantation, glaucoma, and macular edema, were not statistically different between the two groups. An immunosuppressive treatment with biological drugs can improve the visual outcome after cataract surgery in patients with JIA-associated uveitis, but it does not significantly reduce postoperative ocular complications.
2021
10
11
1
9
Cataract Surgery with Intraocular Lens Implantation in Juvenile Idiopathic Arthritis-Associated Uveitis: Outcomes in the Era of Biological Therapy / Bolletta, Elena; Coassin, Marco; Iannetta, Danilo; Mastrofilippo, Valentina; Aldigeri, Raffaella; Invernizzi, Alessandro; de Simone, Luca; Gozzi, Fabrizio; De Fanti, Alessandro; Cappella, Michela; Adani, Chantal; Neri, Alberto; Moramarco, Antonio; De Maria, Michele; Salvarani, Carlo; Fontana, Luigi; Cimino, Luca. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:11(2021), pp. 1-9. [10.3390/jcm10112437]
Bolletta, Elena; Coassin, Marco; Iannetta, Danilo; Mastrofilippo, Valentina; Aldigeri, Raffaella; Invernizzi, Alessandro; de Simone, Luca; Gozzi, Fabr...espandi
File in questo prodotto:
File Dimensione Formato  
jcm-10-02437.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 993.44 kB
Formato Adobe PDF
993.44 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1252409
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 6
social impact