Phosphorylated alpha-synuclein (p-syn) in dermal nerves of patients with isolated REM sleep behavior disorder (iRBD) is detectable by immunofluorescence-labeling. Skin-biopsy-p-syn-positivity was recently postulated to be a prodromal marker of Parkinson's disease (PD) or related synucleinopathies. Here, we provide two-to four-year clinical and skin biopsy follow-up data of 33 iRBD patients, whose skin biopsy findings at baseline were reported in 2017.
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study / Doppler, K; Antelmi, E; Kuzkina, A; Donadio, V; Incensi, A; Plazzi, G; Pizza, F; Marelli, S; Ferini-Strambi, L; Tinazzi, M; Mayer, G; Sittig, E; Booij, J; Sedghi, A; Oertel, W H; Volkmann, J; Sommer, C; Janzen, A; Liguori, R. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - (2021), pp. N/A-N/A. [10.1016/j.parkreldis.2021.04.007]
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study
Plazzi, G;
2021
Abstract
Phosphorylated alpha-synuclein (p-syn) in dermal nerves of patients with isolated REM sleep behavior disorder (iRBD) is detectable by immunofluorescence-labeling. Skin-biopsy-p-syn-positivity was recently postulated to be a prodromal marker of Parkinson's disease (PD) or related synucleinopathies. Here, we provide two-to four-year clinical and skin biopsy follow-up data of 33 iRBD patients, whose skin biopsy findings at baseline were reported in 2017.
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