Narcolepsy is a rare, chronic, and disabling central nervous system hypersomnia; two forms can be recognized: narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Its etiology is still largely unknown, but studies have reported a strong association between NT1 and HLA, as well as a pathogenic association with the deficiency of cerebrospinal hypocretin-1. Thus, the most reliable pathogenic hypothesis is an autoimmune process destroying hypothalamic hypocretin-producing cells. A definitive cure for narcolepsy is not available to date, and although the research in the field is highly promising, up to now, current treatments have aimed to reduce the symptoms by means of different pharmacological approaches. Moreover, overall narcolepsy symptoms management can also benefit from non-pharmacological approaches such as cognitive behavioral therapies (CBTs) and psychosocial interventions to improve the patients' quality of life in both adult and pediatric-affected individuals as well as the well-being of their families. In this review, we summarize the available therapeutic options for narcolepsy, including the pharmacological, behavioral, and psychosocial interventions.

A practical guide to the pharmacological and behavioral therapy of Narcolepsy / Franceschini, Christian; Pizza, Fabio; Cavalli, Francesca; Plazzi, Giuseppe. - In: NEUROTHERAPEUTICS. - ISSN 1933-7213. - 18:1(2021), pp. 6-19. [10.1007/s13311-021-01051-4]

A practical guide to the pharmacological and behavioral therapy of Narcolepsy

Plazzi, Giuseppe
2021

Abstract

Narcolepsy is a rare, chronic, and disabling central nervous system hypersomnia; two forms can be recognized: narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Its etiology is still largely unknown, but studies have reported a strong association between NT1 and HLA, as well as a pathogenic association with the deficiency of cerebrospinal hypocretin-1. Thus, the most reliable pathogenic hypothesis is an autoimmune process destroying hypothalamic hypocretin-producing cells. A definitive cure for narcolepsy is not available to date, and although the research in the field is highly promising, up to now, current treatments have aimed to reduce the symptoms by means of different pharmacological approaches. Moreover, overall narcolepsy symptoms management can also benefit from non-pharmacological approaches such as cognitive behavioral therapies (CBTs) and psychosocial interventions to improve the patients' quality of life in both adult and pediatric-affected individuals as well as the well-being of their families. In this review, we summarize the available therapeutic options for narcolepsy, including the pharmacological, behavioral, and psychosocial interventions.
2021
18
1
6
19
A practical guide to the pharmacological and behavioral therapy of Narcolepsy / Franceschini, Christian; Pizza, Fabio; Cavalli, Francesca; Plazzi, Giuseppe. - In: NEUROTHERAPEUTICS. - ISSN 1933-7213. - 18:1(2021), pp. 6-19. [10.1007/s13311-021-01051-4]
Franceschini, Christian; Pizza, Fabio; Cavalli, Francesca; Plazzi, Giuseppe
File in questo prodotto:
File Dimensione Formato  
s13311-021-01051-4.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 808.95 kB
Formato Adobe PDF
808.95 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1251560
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 15
social impact