Perilipins are conserved proteins that decorate intracellular lipid droplets and are essential for lipid metabolism. To date, there is limited knowledge on their expression in human brain or their involvement in brain aging and neurodegeneration. The aim of this study was to characterise the expression levels of perilipins (Plin1-Plin5) in different cerebral areas from subjects of different age, with or without signs of neurodegeneration.
Expression pattern of perilipins in human brain during aging and in Alzheimer's disease / Conte, Maria; Medici, Valentina; Malagoli, Davide; Chiariello, Antonio; Cirrincione, Alice; Davin, Annalisa; Chikhladze, Maia; Vasuri, Francesco; Legname, Giuseppe; Ferrer, Isidre; Vanni, Silvia; Marcon, Gabriella; Poloni, Tino Emanuele; Guaita, Antonio; Franceschi, Claudio; Salvioli, Stefano. - In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. - ISSN 0305-1846. - 48:1(2022), pp. 1-14. [10.1111/nan.12756]
Expression pattern of perilipins in human brain during aging and in Alzheimer's disease
Malagoli, Davide;
2022
Abstract
Perilipins are conserved proteins that decorate intracellular lipid droplets and are essential for lipid metabolism. To date, there is limited knowledge on their expression in human brain or their involvement in brain aging and neurodegeneration. The aim of this study was to characterise the expression levels of perilipins (Plin1-Plin5) in different cerebral areas from subjects of different age, with or without signs of neurodegeneration.
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