We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3' untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR / Vandenbergh, David J.; Persico, Antonio M.; Hawkins, Anita L.; Griffin, Constance A.; Li, Xiang; Jabs, Ethylin Wang; Uhl, George R.. - In: GENOMICS. - ISSN 0888-7543. - 14:4(1992), pp. 1104-1106. [10.1016/S0888-7543(05)80138-7]
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
Persico, Antonio M.;
1992
Abstract
We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3' untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.
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