Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells visualized at postnatal day-1 (P1) by ISEL+ or TUNEL staining was significantly reduced in the striatum, thalamus/hypothalamus, cerebral cortex and hippocampus of 5-HTT knockout mice, compared to wild type and heterozygote mice, with differences displaying an increasing fronto-caudal gradient and regional specificity. These findings underscore 5-HT roles in the regulation of programmed cell death during brain development, and spur interest into pharmacological interventions aimed at relieving pathological apoptosis by potentiating serotoninergic neurotransmission.

Reduced programmed cell death in brains of serotonin transporter knockout mice / Persico, Antonio M; Baldi, Alfonso; Dell'Acqua, Maria Luisa; Moessner, Rainald; Murphy, Dennis L; Lesch, Klaus-Peter; Keller, Flavio. - In: NEUROREPORT. - ISSN 0959-4965. - 14:3(2003), pp. 341-344. [10.1097/00001756-200303030-00009]

Reduced programmed cell death in brains of serotonin transporter knockout mice

Persico, Antonio M;
2003

Abstract

Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells visualized at postnatal day-1 (P1) by ISEL+ or TUNEL staining was significantly reduced in the striatum, thalamus/hypothalamus, cerebral cortex and hippocampus of 5-HTT knockout mice, compared to wild type and heterozygote mice, with differences displaying an increasing fronto-caudal gradient and regional specificity. These findings underscore 5-HT roles in the regulation of programmed cell death during brain development, and spur interest into pharmacological interventions aimed at relieving pathological apoptosis by potentiating serotoninergic neurotransmission.
2003
14
3
341
344
Reduced programmed cell death in brains of serotonin transporter knockout mice / Persico, Antonio M; Baldi, Alfonso; Dell'Acqua, Maria Luisa; Moessner, Rainald; Murphy, Dennis L; Lesch, Klaus-Peter; Keller, Flavio. - In: NEUROREPORT. - ISSN 0959-4965. - 14:3(2003), pp. 341-344. [10.1097/00001756-200303030-00009]
Persico, Antonio M; Baldi, Alfonso; Dell'Acqua, Maria Luisa; Moessner, Rainald; Murphy, Dennis L; Lesch, Klaus-Peter; Keller, Flavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1250895
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