From invertebrates to humans, serotonin (5-HT) exerts structural effects especially during development. The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and possibly by modulating the intracellular redox state of the cell. This chapter addresses 5-HT trophic effects on developing neural and non-neural mammalian cells, and summarizes SERT roles in 5HT-mediated structural effects from basic neurodevelopment to human teratology.
Developmental roles of the serotonin transporter / Persico, A. M.. - (2010), pp. 78-104. [10.1017/CBO9780511729935.004]
Developmental roles of the serotonin transporter
Persico A. M.
2010
Abstract
From invertebrates to humans, serotonin (5-HT) exerts structural effects especially during development. The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and possibly by modulating the intracellular redox state of the cell. This chapter addresses 5-HT trophic effects on developing neural and non-neural mammalian cells, and summarizes SERT roles in 5HT-mediated structural effects from basic neurodevelopment to human teratology.
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