Objective: To evaluate the response of cardiovascular risk factors to the treatment of climacteric symptoms. Methods: In this prospective study, women reporting climacteric symptoms were randomized to 3 months of treatment with either acupuncture (n ¼ 19), phytoestrogens (75 mg soy isoflavones, BID; n ¼ 22), or low-dose hormone therapy (HT; 0.3 mg conjugated equine oestrogens plus 1.5 mg medroxyprogesterone acetate; n ¼ 20). Greene’s climacteric scale, blood pressure (BP), lipids, glucose, insulin, and homeostatic model assessment of insulin resistance were assessed before and after treatment. Observed changes were compared by analysis of variance. Results: HT and acupuncture reduced Greene climacteric score to a similar extent, but the effect of phytoestrogens was significantly lower (P < 0.05). With acupuncture, systolic (-7.4 ± 15.3 mm Hg; P < 0.05) and diastolic BP (-8.3 ± 7.7mm Hg; P < 0.01) decreased, and the same occurred with phytoestrogens (-8.4 ± 9.0 mm Hg [P < 0.01] and -6.6 ± 7.9 mm Hg [P < 0.01]). Neither BP systolic (1.9 ± 17.5 mm Hg) nor BP diastolic (-1.4 ± 9.6 mm Hg) changed during HT. Low-density lipoprotein cholesterol decreased with phytoestrogens (-9.9 ± 19.6 mg/ dL; P < 0.05), and triglycerides increased with both HT (34.5 ± 12.2 mg/dL; P < 0.01) and phytoestrogens (17.41 ± 24.4 mg/dL; P < 0.01). A slight but significant increase in homeostatic model assessment of insulin resistance (0.14 ± 0.5; P < 0.05) was observed after HT. Conclusions: Treatment of climacteric symptoms with acupuncture and phytoestrogens, but not HT, is associated with a clear BP reduction, and phytoestrogens with potentially positive alterations in low-density lipoprotein cholesterol level.
Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones / Palma, F.; Fontanesi, F.; Neri, I.; Xholli, A.; Facchinetti, F.; Cagnacci, A.. - In: MENOPAUSE. - ISSN 1072-3714. - 27:9(2020), pp. 1060-1065. [10.1097/GME.0000000000001626]
Data di pubblicazione: | 2020 | |
Titolo: | Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones | |
Autore/i: | Palma, F.; Fontanesi, F.; Neri, I.; Xholli, A.; Facchinetti, F.; Cagnacci, A. | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/GME.0000000000001626 | |
Rivista: | ||
Volume: | 27 | |
Fascicolo: | 9 | |
Pagina iniziale: | 1060 | |
Pagina finale: | 1065 | |
Codice identificativo ISI: | WOS:000612089000016 | |
Codice identificativo Scopus: | 2-s2.0-85090078422 | |
Codice identificativo Pubmed: | 32852460 | |
Citazione: | Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones / Palma, F.; Fontanesi, F.; Neri, I.; Xholli, A.; Facchinetti, F.; Cagnacci, A.. - In: MENOPAUSE. - ISSN 1072-3714. - 27:9(2020), pp. 1060-1065. [10.1097/GME.0000000000001626] | |
Tipologia | Articolo su rivista |
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