The complex mechanisms underlying homeobox genes expression involve regulation at transcriptional, posttranscriptional and translational levels. The multiple transcripts of the human HOX-5.1 gene are expressed differentially in tissue- and stage-specific patterns during embryogenesis, and differentially induced by retinoic acid (RA) in human embryonal carcinoma (EC) NT2/D1 cells. We have sequenced 6.3 Kb of the genomic region containing the HOX-5.1 gene and analyzed its mechanisms of expression. Two alternative promoters underlie the transcription of two classes of HOX-5.1-specific mRNAs. These classes differ in tissue and subcellular distribution, induction by RA, structure of the 5'-UT region and mRNA stability: these features are compatible with a differential function of the two classes of transcripts in embryogenesis. © 1990 Oxford University Press.

Molecular mechanisms underlying the expression of the human HOX-5.1 gene / Cianetti, L.; Cristofaro, A. D.; Zappavigna, V.; Bottero, L.; Boccoli, G.; Testa, U.; Russo, G.; Boncinelli, E.; Peschle, C.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 18:15(1990), pp. 4361-4368. [10.1093/nar/18.15.4361]

Molecular mechanisms underlying the expression of the human HOX-5.1 gene

Zappavigna V.;
1990

Abstract

The complex mechanisms underlying homeobox genes expression involve regulation at transcriptional, posttranscriptional and translational levels. The multiple transcripts of the human HOX-5.1 gene are expressed differentially in tissue- and stage-specific patterns during embryogenesis, and differentially induced by retinoic acid (RA) in human embryonal carcinoma (EC) NT2/D1 cells. We have sequenced 6.3 Kb of the genomic region containing the HOX-5.1 gene and analyzed its mechanisms of expression. Two alternative promoters underlie the transcription of two classes of HOX-5.1-specific mRNAs. These classes differ in tissue and subcellular distribution, induction by RA, structure of the 5'-UT region and mRNA stability: these features are compatible with a differential function of the two classes of transcripts in embryogenesis. © 1990 Oxford University Press.
1990
18
15
4361
4368
Molecular mechanisms underlying the expression of the human HOX-5.1 gene / Cianetti, L.; Cristofaro, A. D.; Zappavigna, V.; Bottero, L.; Boccoli, G.; Testa, U.; Russo, G.; Boncinelli, E.; Peschle, C.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 18:15(1990), pp. 4361-4368. [10.1093/nar/18.15.4361]
Cianetti, L.; Cristofaro, A. D.; Zappavigna, V.; Bottero, L.; Boccoli, G.; Testa, U.; Russo, G.; Boncinelli, E.; Peschle, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1249632
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