We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.

The long-standing history of Corynebacterium parvum, immunity, and viruses / Palmieri, B.; Vadala, M.; Roncati, L.; Garelli, A.; Scandone, F.; Bondi, M.; Cermelli, C.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 92:11(2020), pp. 2429-2439. [10.1002/jmv.26100]

The long-standing history of Corynebacterium parvum, immunity, and viruses

Cermelli C.
2020

Abstract

We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.
2020
92
11
2429
2439
The long-standing history of Corynebacterium parvum, immunity, and viruses / Palmieri, B.; Vadala, M.; Roncati, L.; Garelli, A.; Scandone, F.; Bondi, M.; Cermelli, C.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 92:11(2020), pp. 2429-2439. [10.1002/jmv.26100]
Palmieri, B.; Vadala, M.; Roncati, L.; Garelli, A.; Scandone, F.; Bondi, M.; Cermelli, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1249412
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