The changing scenario of hepatitis B virus therapy has encouraged the organisation of a workshop, endorsed by three Italian scientific societies, aimed at defining the current recommendations for hepatitis B virus treatment. Liver histology and stage of disease remain fundamental for treatment decisions; interferon and nucleoside/nucleotide analogues-based therapy represent different strategies for different phases of the hepatitis B virus disease. The recommendations defined: new and lower cut-off of hepatitis B virus-DNA for eligibility to therapy according to disease stage, how to optimise the use of nucleoside/nucleotide analogues and to individualise the monitoring of response and what to do with treatment failures. Specific recommendations have also been given for cirrhosis patients, those immune suppressed and co-infected with HIV and other hepatitis viruses. © 2008 Editrice Gastroenterologica Italiana S.r.l.
Treatment of chronic hepatitis B: Recommendations from an Italian workshop / Carosi, G.; Rizzetto, M.; Andreone, P.; Angelico, M.; Ascione, A.; Caporaso, N.; Fagiuolim, S.; Fattovich, G.; Mondelli, M.; Niro, G. A.; Pontisso, P.; Bonino, F.; Perno, C. F.; Prati, D.; Andreoni, M.; Angarano, G.; Annicchiarico, E.; Boncoraglio, R.; Brustia, D.; Calabrese, N.; Carlotto, A.; Cavalletto, L.; Cavina, M.; Chessa, L.; Croce, G.; De Sanctis, G.; Di Candilo, F.; Fabris, P.; Fracassetti, O.; Lanza, A. G.; Giuberti, T.; Guazzotti, G.; Iacovazzi, T.; Iovinella, V.; Izzi, A.; Loperfido, P.; Magni, C. F.; Marino, N.; Messina, V.; Michelone, G.; Morante, R.; Moretti, A.; Nasta, P.; Nauri, L.; Paffetti, A.; Pasino, M.; Perboni, G.; Petrelli, E.; Picciotto, A.; Pozzi, M.; Purificato, F.; Re, T.; Rinaldi, R.; Sani, S.; Santoro, R.; Schioppa, O.; Scotto, G.; Siciliano, M.; Sorbello, O.; Squadrito, G.; Taddei, M. T.; Traversa, A.; Tundo, P.; Venezia, G.; Vilardo, L.; Zignego, A. L.; Zoncada, A.; Zuin, M.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 40:8(2008), pp. 603-617. [10.1016/j.dld.2008.03.011]
Treatment of chronic hepatitis B: Recommendations from an Italian workshop
Andreone P.;
2008
Abstract
The changing scenario of hepatitis B virus therapy has encouraged the organisation of a workshop, endorsed by three Italian scientific societies, aimed at defining the current recommendations for hepatitis B virus treatment. Liver histology and stage of disease remain fundamental for treatment decisions; interferon and nucleoside/nucleotide analogues-based therapy represent different strategies for different phases of the hepatitis B virus disease. The recommendations defined: new and lower cut-off of hepatitis B virus-DNA for eligibility to therapy according to disease stage, how to optimise the use of nucleoside/nucleotide analogues and to individualise the monitoring of response and what to do with treatment failures. Specific recommendations have also been given for cirrhosis patients, those immune suppressed and co-infected with HIV and other hepatitis viruses. © 2008 Editrice Gastroenterologica Italiana S.r.l.
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