Chronic Hepatitis C is associated with many extrahepatic manifestations. Central nervous system is frequently involved, but the pathophysiological mechanisms are not fully understood. Local and systemic inflammation, ischemia, immune-mediated phenomena have been described in this context. Clinical manifestations include cognitive alterations, stroke, depression and demyelinating phenomena. It is unclear if cognitive deficits can be improved or resolved with viral eradication and to understand this, could have important therapeutical implications.
Cognitive, neurological and psychiatric disorders occurring in Hepatitis C Virus infection / Tassi, A.; Gitto, S.; Piras, C.; Cursaro, C.; Alicandro, T.; Margotti, M.; Rivi, M.; Andreone, P.. - In: MINERVA MEDICA. - ISSN 0026-4806. - 112:2(2021), pp. 238-245. [10.23736/S0026-4806.21.07388-2]
Cognitive, neurological and psychiatric disorders occurring in Hepatitis C Virus infection
Andreone P.
2021
Abstract
Chronic Hepatitis C is associated with many extrahepatic manifestations. Central nervous system is frequently involved, but the pathophysiological mechanisms are not fully understood. Local and systemic inflammation, ischemia, immune-mediated phenomena have been described in this context. Clinical manifestations include cognitive alterations, stroke, depression and demyelinating phenomena. It is unclear if cognitive deficits can be improved or resolved with viral eradication and to understand this, could have important therapeutical implications.
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