High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ‐aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany
Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation / Kozikowski, A. P.; Ma, D.; Romeo, E.; Auta, J.; Papadopoulos, V.; Puia, G.; Costa, E.; Guidotti, A.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION IN ENGLISH. - ISSN 0570-0833. - 31:8(1992), pp. 1060-1062. [10.1002/anie.199210601]
Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation
Puia G.;
1992
Abstract
High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ‐aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany
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