High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ‐aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany

Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation / Kozikowski, A. P.; Ma, D.; Romeo, E.; Auta, J.; Papadopoulos, V.; Puia, G.; Costa, E.; Guidotti, A.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION IN ENGLISH. - ISSN 0570-0833. - 31:8(1992), pp. 1060-1062. [10.1002/anie.199210601]

Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation

Puia G.;
1992

Abstract

High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ‐aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany
1992
31
8
1060
1062
Synthesis of (2‐Arylindol‐3‐yl)acetamides as Probes of Mitochondrial Steroidogenesis—A New Mechanism for GABAA Receptor Modulation / Kozikowski, A. P.; Ma, D.; Romeo, E.; Auta, J.; Papadopoulos, V.; Puia, G.; Costa, E.; Guidotti, A.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION IN ENGLISH. - ISSN 0570-0833. - 31:8(1992), pp. 1060-1062. [10.1002/anie.199210601]
Kozikowski, A. P.; Ma, D.; Romeo, E.; Auta, J.; Papadopoulos, V.; Puia, G.; Costa, E.; Guidotti, A.
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