An abnormal human hemoglobin was found in association with β-thalassemia in a hemolysate from an 11-year-old healthy child living in Bologna (northern) Italy). Structural studies demonstrated a previously unreported amino acid substitution, β 61 (E5) Lys → Met (this is an external residue). The new variant has been named Hb Bologna, and is characterized by a reduced oxygen affinity. Family studies indicated that the variant had been inherited from the father, a 41-year-old male of Southern Italian origin. Also, a brother of the propositus was found to be an abnormal Hb carrier. © 1981.
Hemoglobin bologna (α2β2 61 (E5) Lys → Met) An abnormal human hemoglobin wlth low oxygen affinity / Marinucci, M.; Giuliani, A.; Maffi, D.; Massa, A.; Giampaolo, A.; Mavilio, F.; Zannotti, M.; Tentori, L.. - In: BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE. - ISSN 0005-2795. - 668:2(1981), pp. 209-215. [10.1016/0005-2795(81)90028-3]
Hemoglobin bologna (α2β2 61 (E5) Lys → Met) An abnormal human hemoglobin wlth low oxygen affinity
Mavilio F.;
1981
Abstract
An abnormal human hemoglobin was found in association with β-thalassemia in a hemolysate from an 11-year-old healthy child living in Bologna (northern) Italy). Structural studies demonstrated a previously unreported amino acid substitution, β 61 (E5) Lys → Met (this is an external residue). The new variant has been named Hb Bologna, and is characterized by a reduced oxygen affinity. Family studies indicated that the variant had been inherited from the father, a 41-year-old male of Southern Italian origin. Also, a brother of the propositus was found to be an abnormal Hb carrier. © 1981.
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