An α-chain variant hemoglobin was found in the hemolysate of a 21-year-old healthy male living in Bari (Puglia, Italy). Structural studies demonstrated a previously unreported amino acid substitution, α2 45 (CD3) His → Gln β2, involving a distal heme contact. The new variant has been named Hb Bari. Its electrophoretic behavior was the same as for Hb A; it was stable to both isopropanol and heat denaturation and exhibited normal functional properties, with respect to whole blood and stripped hemolysate studies. The level of Hb Bari was about 20% in the observed carrier. No relative was available for further investigations. © 1980.
A new human hemoglobin variant: Hb Bari (α2 45 (CD3) His → Gln β2) / Marinucci, M.; Mavilio, F.; Tentori, L.; D'Erasmo, F.; Colapietro, A.; de Stasio, G.; di Fonzo, S.. - In: BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE. - ISSN 0005-2795. - 622:2(1980), pp. 315-319. [10.1016/0005-2795(80)90042-2]
A new human hemoglobin variant: Hb Bari (α2 45 (CD3) His → Gln β2)
Mavilio F.;
1980
Abstract
An α-chain variant hemoglobin was found in the hemolysate of a 21-year-old healthy male living in Bari (Puglia, Italy). Structural studies demonstrated a previously unreported amino acid substitution, α2 45 (CD3) His → Gln β2, involving a distal heme contact. The new variant has been named Hb Bari. Its electrophoretic behavior was the same as for Hb A; it was stable to both isopropanol and heat denaturation and exhibited normal functional properties, with respect to whole blood and stripped hemolysate studies. The level of Hb Bari was about 20% in the observed carrier. No relative was available for further investigations. © 1980.
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