An abnormal, fast moving hemoglobin was noted in a 34-yr-old male patient living in Legnano (northern Italy) affected with renal failure and iron deficiency anemia, not related to the presence of the Hb variant. Structural studies have demonstrated a previously undescribed amino acid substitution, α 141 Arg → Leu. This new variant has been named Hb Legnano, and is characterized by an increased oxygen affinity and a low cooperativity, at least as far as preliminary functional studies carried out on whole blood have indicated. Family studies are reported: three other heterozygous carriers were observed among the relatives of the propositus, all showing a mild polycythemia which, however, does not seem to produce appreciable clinical consequences. © 1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Hemoglobin legnano (α2 141 (HC3) arg → leu β2): A new abnormal human hemoglobin with high oxygen affinity / Mavilio, F.; Marinucci, M.; Tentori, L.; Fontanarosa, P. P.; Rossi, U.; Biagiotti, S.. - In: HEMOGLOBIN. - ISSN 0363-0269. - 2:3(1978), pp. 249-259. [10.3109/03630267809007070]
Hemoglobin legnano (α2 141 (HC3) arg → leu β2): A new abnormal human hemoglobin with high oxygen affinity
Mavilio F.;
1978
Abstract
An abnormal, fast moving hemoglobin was noted in a 34-yr-old male patient living in Legnano (northern Italy) affected with renal failure and iron deficiency anemia, not related to the presence of the Hb variant. Structural studies have demonstrated a previously undescribed amino acid substitution, α 141 Arg → Leu. This new variant has been named Hb Legnano, and is characterized by an increased oxygen affinity and a low cooperativity, at least as far as preliminary functional studies carried out on whole blood have indicated. Family studies are reported: three other heterozygous carriers were observed among the relatives of the propositus, all showing a mild polycythemia which, however, does not seem to produce appreciable clinical consequences. © 1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.Pubblicazioni consigliate
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