The level of expression of the myeloperoxidase gene (MPO), strictly associated with myeloid differentiation as well as of some cell cycle related genes, such as c-myc and Histone H3, was evaluated by northern blot analysis in blast cells of 4 cases of Acute Promyelocytic Leukemia. MPO gene expression was found to be not related to the growth activity of the cell population. It appears that the differentiation arrest which occurs in the majority of the blast cells is not strictly associated with the proliferation impairment.
Possible correlations between proliferation and differentiation in blast cells of acute promyelocytic leukemia: A molecular study / Tagliafico, E.; Manfredini, R.; Selleri, L.; Zucchini, P.; Ceccherelli, G.. - In: MEDICINA. - ISSN 0392-6516. - 8:4(1988), pp. 425-428.
Possible correlations between proliferation and differentiation in blast cells of acute promyelocytic leukemia: A molecular study
Tagliafico E.;Manfredini R.;
1988
Abstract
The level of expression of the myeloperoxidase gene (MPO), strictly associated with myeloid differentiation as well as of some cell cycle related genes, such as c-myc and Histone H3, was evaluated by northern blot analysis in blast cells of 4 cases of Acute Promyelocytic Leukemia. MPO gene expression was found to be not related to the growth activity of the cell population. It appears that the differentiation arrest which occurs in the majority of the blast cells is not strictly associated with the proliferation impairment.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
