The effect of repeated administration of d-amphetamine (AMP), methylphenidate (MP) and nomifensine (NOM) on dopamine receptors, striatal adenylate cyclase and tyrosine hydroxylase was studied. No one of the three stimulating drugs changed the receptor number or their affinity to haloperidol specific binding. Adenylate cyclase from rats treated with NOM showed a subsensitivity to the stimulation by dopamine. AMP treatment decreased the activity of striatal tyrosine hydroxylase. MP was ineffective in all the parameters studied. These results show that drugs believed to belong to the same class of stimulants are different in their effect on the CNS adaptive mechanisms.
Different adaptive responses by rat striatal dopamine synthetic and receptor mechanisms after repeated treatment with d-amphetamine, methylphenidate and nomifensine / Algeri, S.; Brunello, N.; Vantini, G.. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 12:7(1980), pp. 675-681.