Oral treatment of rats withGinkgo biloba extract (Gb) elicited a biphasic effect on normetanephrine (NMN) content of cerebral cortex; an initial decrease was evident after 45 minutes, followed by a marked increase that was evident after 14 days. Chronic treatment with Gb led to decreases in the density of3H -dihydroalprenolol binding (after 27 days or 2 months) and in isoproterenol-stimulated adenylate cyclase activity (after 2 months) of the cerebral cortex. Taken together, these results indicate that the effects of Gb on the central β-adrenergic system might be involved in its therapeutic actions. © 1985 The Italian Pharmacological Society.
Effects of an extract of Ginkgo Biloba on noradrenergic systems of rat cerebral cortex / Brunello, N.; Racagni, G.; Clostre, F.; Drieu, K.; Braquet, P.. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 17:11(1985), pp. 1063-1072. [10.1016/0031-6989(85)90112-2]