The high-affinity binding sites for mianserin and imipramine appear to be located in different neurons of rat brain. Studies in which lesions were produced with 5,7-dihydroxytryptamine and other studies in which the 5-hydroxytryptamine content was decreased with p-chlorophenylalanine indicate that some of the imipramine binding sites are on serotonin axon terminals and others are on nonserotonergic synapses. The sites that bind mianserin are on postsynaptic serotonin sites as well as on synapses of other neuronal systems. Copyright © 1982 AAAS.
Different synaptic location of mianserin and imipramine binding sites / Brunello, N.; Chuang, D. M.; Costa, E.. - In: SCIENCE. - ISSN 0036-8075. - 215:4536(1982), pp. 1112-1115. [10.1126/science.6278586]
Different synaptic location of mianserin and imipramine binding sites
Brunello N.;
1982
Abstract
The high-affinity binding sites for mianserin and imipramine appear to be located in different neurons of rat brain. Studies in which lesions were produced with 5,7-dihydroxytryptamine and other studies in which the 5-hydroxytryptamine content was decreased with p-chlorophenylalanine indicate that some of the imipramine binding sites are on serotonin axon terminals and others are on nonserotonergic synapses. The sites that bind mianserin are on postsynaptic serotonin sites as well as on synapses of other neuronal systems. Copyright © 1982 AAAS.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
