In the present work we analyze the effects of thymosin α1 treatment on the number and the candidacidal activity of murine polymorphonuclear leukocytes. The data we obtained showed that the treatment with thymosin α1 (100 μg/Kg s.c.) 10, 8, 6, 4 and 2 days before the assay may result in a significant numerical augmentation of circulating polymorphonucleates in the peripheral blood, as well as of their candidacidal activity when measured in vitro in both a 4-h cytotoxicity assay and a CFU inhibition assay against Candida albicans microorganisms. On the other hand, a single dose of thymosin α1 (500 μg/Kg s.c.) 3 days before the assay resulted in a significant decrease of the candidacidal activity of mouse polymorphonucleates. The data are discussed with regard to the immunomodulating capacity of thymison α1 and to our previously reported observation concerning the ability of the drug to modulate the resistance against systemic Candida albicans infection.
Modulation of polymorphonucleate-mediated cytotoxicity against Candida albicans by thymosin α1 / Bistoni, F.; Baccarini, M.; Blasi, E.; Riccardi, C.; Marconi, P.; Garaci, E.. - In: THYMUS. - ISSN 0165-6090. - 7:2(1985), pp. 69-84.
Modulation of polymorphonucleate-mediated cytotoxicity against Candida albicans by thymosin α1
Blasi E.;
1985
Abstract
In the present work we analyze the effects of thymosin α1 treatment on the number and the candidacidal activity of murine polymorphonuclear leukocytes. The data we obtained showed that the treatment with thymosin α1 (100 μg/Kg s.c.) 10, 8, 6, 4 and 2 days before the assay may result in a significant numerical augmentation of circulating polymorphonucleates in the peripheral blood, as well as of their candidacidal activity when measured in vitro in both a 4-h cytotoxicity assay and a CFU inhibition assay against Candida albicans microorganisms. On the other hand, a single dose of thymosin α1 (500 μg/Kg s.c.) 3 days before the assay resulted in a significant decrease of the candidacidal activity of mouse polymorphonucleates. The data are discussed with regard to the immunomodulating capacity of thymison α1 and to our previously reported observation concerning the ability of the drug to modulate the resistance against systemic Candida albicans infection.
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