We evaluated the effects of systemic infection by Herpes bovis virus 2 (HBV-2) on a murine experimental system. We provide evidence that such infection is lethal for the immunocompromised but not for the immunocompetent mouse in which a biphasic immune response is elicited. In particular, 1 day post-infection, we observed a rapid transient depression induced by the virus, as documented by a decrease in peripheral leukocyte counts, mitogenic spleen cell response and resistance to a secondary microbial challenge. Later, HBV-2 infection boosted cytokine secretion and enhanced antimicrobial and antitumoral activities by the splenic district. In conclusion, our experimental model discloses some immunological aspects underlying the complex host-virus interaction.

Systemic infection with Herpes bovis virus 2 evokes a biphasic immune response in the mouse / Puliti, M.; Cenci, E.; Vecchiarelli, A.; Blasi, E.; Merletti, L.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 17:4(1994), pp. 281-289.

Systemic infection with Herpes bovis virus 2 evokes a biphasic immune response in the mouse

Blasi E.;
1994

Abstract

We evaluated the effects of systemic infection by Herpes bovis virus 2 (HBV-2) on a murine experimental system. We provide evidence that such infection is lethal for the immunocompromised but not for the immunocompetent mouse in which a biphasic immune response is elicited. In particular, 1 day post-infection, we observed a rapid transient depression induced by the virus, as documented by a decrease in peripheral leukocyte counts, mitogenic spleen cell response and resistance to a secondary microbial challenge. Later, HBV-2 infection boosted cytokine secretion and enhanced antimicrobial and antitumoral activities by the splenic district. In conclusion, our experimental model discloses some immunological aspects underlying the complex host-virus interaction.
1994
17
4
281
289
Systemic infection with Herpes bovis virus 2 evokes a biphasic immune response in the mouse / Puliti, M.; Cenci, E.; Vecchiarelli, A.; Blasi, E.; Merletti, L.. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 17:4(1994), pp. 281-289.
Puliti, M.; Cenci, E.; Vecchiarelli, A.; Blasi, E.; Merletti, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1247210
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