Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-γ in macrophage activation. The findings suggest that the capacity of MuIFN-γ to activate macrophages without the need for a second triggering stimulus is related to assay conditions and, most especially, the strain of mouse used to provide the macrophages.
The strain of mouse and assay conditions influence whether MuIFN-γ primes or activates macrophages for tumor cell killing / Pace, J. L.; Varesio, L.; Russell, S. W.; Blasi, E.. - In: JOURNAL OF LEUKOCYTE BIOLOGY. - ISSN 0741-5400. - 37:4(1985), pp. 475-479. [10.1002/jlb.37.4.475]
The strain of mouse and assay conditions influence whether MuIFN-γ primes or activates macrophages for tumor cell killing
Blasi E.
1985
Abstract
Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-γ in macrophage activation. The findings suggest that the capacity of MuIFN-γ to activate macrophages without the need for a second triggering stimulus is related to assay conditions and, most especially, the strain of mouse used to provide the macrophages.
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