Introduction: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). Areas covered: In view of the recent knowledge, changes in nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplemenation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. Expert opinion: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs) / Facchinetti, F.; Cavalli, P.; Copp, A. J.; D'Anna, R.; Kandaraki, E.; Greene, N. D. E.; Unfer, V.. - In: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. - ISSN 1742-5255. - 16:12(2020), pp. 1187-1198. [10.1080/17425255.2020.1828344]

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)

Facchinetti F.;Unfer V.
2020

Abstract

Introduction: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). Areas covered: In view of the recent knowledge, changes in nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplemenation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. Expert opinion: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.
2020
16
12
1187
1198
An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs) / Facchinetti, F.; Cavalli, P.; Copp, A. J.; D'Anna, R.; Kandaraki, E.; Greene, N. D. E.; Unfer, V.. - In: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. - ISSN 1742-5255. - 16:12(2020), pp. 1187-1198. [10.1080/17425255.2020.1828344]
Facchinetti, F.; Cavalli, P.; Copp, A. J.; D'Anna, R.; Kandaraki, E.; Greene, N. D. E.; Unfer, V.
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