Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) 29 antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). 30 However, their role remains unclear and only 7-23% of these patients develops clinically overt vas- 31 culitis. We aimed to investigate the clinical, serological and radiological features, and prognosis of 32 anti-MPO-positive interstitial lung disease (ILD) patients. 33 Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing 34 serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clini- 35 cal data, lung function testing, chest high resolution computed tomography (HRCT) pattern, and 36 survival were recorded. 37 Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual 38 interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the pa- 39 tients’ survival. In fact, while the 52-week survival of the overall population was 71.4%±7.5, signif- 40 icantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. 41 Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7% and 41.5% 42 of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. 43 A careful clinical history and evaluation should be always performed in ILD patients with anti- 44 MPO antibodies to early identify patients developing a systemic rheumatic disease.
Interstitial lung disease and anti-myeloperoxidase antibodies: not a simple association / Sebastiani, M; Luppi, F; Sambataro, G; Castillo Villegas, D; Cerri, S; Tomietto, P; Cassone, G; Bocchino, M; Atienza-Mateo, B; Cameli, P; Moya Alvarado, P; Faverio, P; Bargagli, E; Vancheri, C; Gonzalez-Gay, Ma; Clini, E; Salvarani, C; Manfredi, A.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:(2021), pp. 1-8. [10.3390/jcm10122548]
Data di pubblicazione: | 2021 | |
Data di prima pubblicazione: | 9-giu-2021 | |
Titolo: | Interstitial lung disease and anti-myeloperoxidase antibodies: not a simple association | |
Autore/i: | Sebastiani, M; Luppi, F; Sambataro, G; Castillo Villegas, D; Cerri, S; Tomietto, P; Cassone, G; Bocchino, M; Atienza-Mateo, B; Cameli, P; Moya Alvarado, P; Faverio, P; Bargagli, E; Vancheri, C; Gonzalez-Gay, Ma; Clini, E; Salvarani, C; Manfredi, A. | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/jcm10122548 | |
Rivista: | ||
Volume: | 10 | |
Pagina iniziale: | 1 | |
Pagina finale: | 8 | |
Codice identificativo ISI: | WOS:000665895500001 | |
Codice identificativo Scopus: | 2-s2.0-85114080577 | |
Citazione: | Interstitial lung disease and anti-myeloperoxidase antibodies: not a simple association / Sebastiani, M; Luppi, F; Sambataro, G; Castillo Villegas, D; Cerri, S; Tomietto, P; Cassone, G; Bocchino, M; Atienza-Mateo, B; Cameli, P; Moya Alvarado, P; Faverio, P; Bargagli, E; Vancheri, C; Gonzalez-Gay, Ma; Clini, E; Salvarani, C; Manfredi, A.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:(2021), pp. 1-8. [10.3390/jcm10122548] | |
Tipologia | Articolo su rivista |
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Sebastiani (ILD anti-MPO antibodies related- 2021).pdf | Versione dell'editore (versione pubblicata) | Open Access Visualizza/Apri |
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