STUDY OBJECTIVES: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups.METHODS: In this cross-sectional, multicenter study, 106 untreated NT1 patients, enrolled at the time of diagnosis, underwent clinical evaluation, a semi-structured interview (including the Epworth Sleepiness Scale - ESS), nocturnal video-polysomnography and the Multiple Sleep Latency Test (MSLT). Patients were enrolled in order to establish five age-balanced groups (childhood, adolescence, adulthood, middle-aged and seniors).RESULTS: The ESS score showed a significant increase with age, while self-reported diurnal total sleep time was lower in elderly and young adults, with the latter also complaining of automatic behaviors in more than 90% of cases. Children reported the cataplexy attacks to be more frequent (>1/day in 95% of cases). "Recalling an emotional event", "meeting someone unexpectedly", "stress" and "anger" were more frequently reported in adult and elderly patients as possible triggers of cataplexy. Neurophysiological data showed a higher number of SOREMPs on the MSLT in adolescents compared to senior patients and an age-progressive decline in sleep efficiency.CONCLUSIONS: Daytime sleepiness, cataplexy features and triggers, and nocturnal sleep structure showed age-related difference in NT1 patients; this variability may contribute to diagnostic delay and misdiagnosis.

Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype / Lividini, Althea; Pizza, Fabio; Filardi, Marco; Vandi, Stefano; Ingravallo, Francesca; Antelmi, Elena; Bruni, Oliviero; Ilaria Cosentino, Filomena Irene; Ferri, Raffaele; Guarnieri, Biancamaria; Marelli, Sara; Ferini-Strambi, Luigi; Romigi, Andrea; Bonanni, Enrica; Maestri, Michelangelo; Terzaghi, Michele; Manni, Raffaele; Plazzi, Giuseppe. - In: JOURNAL OF CLINICAL SLEEP MEDICINE. - ISSN 1550-9389. - 17:7(2021), pp. 1363-1370. [10.5664/jcsm.9198]

Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype

Plazzi, Giuseppe
2021

Abstract

STUDY OBJECTIVES: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups.METHODS: In this cross-sectional, multicenter study, 106 untreated NT1 patients, enrolled at the time of diagnosis, underwent clinical evaluation, a semi-structured interview (including the Epworth Sleepiness Scale - ESS), nocturnal video-polysomnography and the Multiple Sleep Latency Test (MSLT). Patients were enrolled in order to establish five age-balanced groups (childhood, adolescence, adulthood, middle-aged and seniors).RESULTS: The ESS score showed a significant increase with age, while self-reported diurnal total sleep time was lower in elderly and young adults, with the latter also complaining of automatic behaviors in more than 90% of cases. Children reported the cataplexy attacks to be more frequent (>1/day in 95% of cases). "Recalling an emotional event", "meeting someone unexpectedly", "stress" and "anger" were more frequently reported in adult and elderly patients as possible triggers of cataplexy. Neurophysiological data showed a higher number of SOREMPs on the MSLT in adolescents compared to senior patients and an age-progressive decline in sleep efficiency.CONCLUSIONS: Daytime sleepiness, cataplexy features and triggers, and nocturnal sleep structure showed age-related difference in NT1 patients; this variability may contribute to diagnostic delay and misdiagnosis.
2021
17
7
1363
1370
Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype / Lividini, Althea; Pizza, Fabio; Filardi, Marco; Vandi, Stefano; Ingravallo, Francesca; Antelmi, Elena; Bruni, Oliviero; Ilaria Cosentino, Filomena Irene; Ferri, Raffaele; Guarnieri, Biancamaria; Marelli, Sara; Ferini-Strambi, Luigi; Romigi, Andrea; Bonanni, Enrica; Maestri, Michelangelo; Terzaghi, Michele; Manni, Raffaele; Plazzi, Giuseppe. - In: JOURNAL OF CLINICAL SLEEP MEDICINE. - ISSN 1550-9389. - 17:7(2021), pp. 1363-1370. [10.5664/jcsm.9198]
Lividini, Althea; Pizza, Fabio; Filardi, Marco; Vandi, Stefano; Ingravallo, Francesca; Antelmi, Elena; Bruni, Oliviero; Ilaria Cosentino, Filomena Ire...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1238857
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 17
social impact