Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases. The pathobiology of motor neuron degeneration is still largely unknown, and no effective therapy is available. Heterogeneity and lack of specific disease biomarkers have been appointed as leading reasons for past clinical trial failure, and biomarker discovery is pivotal in today's MND research agenda.In the last decade, neurofilaments (NFs) have emerged as promising biomarkers for the clinical assessment of neurodegeneration. NFs are scaffolding proteins with predominant structural functions contributing to the axonal cytoskeleton of myelinated axons. NFs are released in CSF and peripheral blood as a consequence of axonal degeneration, irrespective of the primary causal event. Due to the current availability of highly-sensitive automated technologies capable of precisely quantify proteins in biofluids in the femtomolar range, it is now possible to reliably measure NFs not only in CSF but also in blood.In this review, we will discuss how NFs are impacting research and clinical management in ALS and other MNDs. Besides contributing to the diagnosis at early stages by differentiating between MNDs with different clinical evolution and severity, NFs may provide a useful tool for the early enrolment of patients in clinical trials. Due to their stability across the disease, NFs convey prognostic information and, on a larger scale, help to stratify patients in homogenous groups. Shortcomings of NFs assessment in biofluids will also be discussed according to the available literature in the attempt to predict the most appropriate use of the biomarker in the MND clinic.

Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers / Zucchi, Elisabetta; Bonetto, Valentina; Sorarù, Gianni; Martinelli, Ilaria; Parchi, Piero; Liguori, Rocco; Mandrioli, Jessica. - In: MOLECULAR NEURODEGENERATION. - ISSN 1750-1326. - 15:1(2020), pp. 1-20. [10.1186/s13024-020-00406-3]

Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers

Zucchi, Elisabetta;Martinelli, Ilaria;Mandrioli, Jessica
2020

Abstract

Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases. The pathobiology of motor neuron degeneration is still largely unknown, and no effective therapy is available. Heterogeneity and lack of specific disease biomarkers have been appointed as leading reasons for past clinical trial failure, and biomarker discovery is pivotal in today's MND research agenda.In the last decade, neurofilaments (NFs) have emerged as promising biomarkers for the clinical assessment of neurodegeneration. NFs are scaffolding proteins with predominant structural functions contributing to the axonal cytoskeleton of myelinated axons. NFs are released in CSF and peripheral blood as a consequence of axonal degeneration, irrespective of the primary causal event. Due to the current availability of highly-sensitive automated technologies capable of precisely quantify proteins in biofluids in the femtomolar range, it is now possible to reliably measure NFs not only in CSF but also in blood.In this review, we will discuss how NFs are impacting research and clinical management in ALS and other MNDs. Besides contributing to the diagnosis at early stages by differentiating between MNDs with different clinical evolution and severity, NFs may provide a useful tool for the early enrolment of patients in clinical trials. Due to their stability across the disease, NFs convey prognostic information and, on a larger scale, help to stratify patients in homogenous groups. Shortcomings of NFs assessment in biofluids will also be discussed according to the available literature in the attempt to predict the most appropriate use of the biomarker in the MND clinic.
2020
15-ott-2020
15
1
1
20
Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers / Zucchi, Elisabetta; Bonetto, Valentina; Sorarù, Gianni; Martinelli, Ilaria; Parchi, Piero; Liguori, Rocco; Mandrioli, Jessica. - In: MOLECULAR NEURODEGENERATION. - ISSN 1750-1326. - 15:1(2020), pp. 1-20. [10.1186/s13024-020-00406-3]
Zucchi, Elisabetta; Bonetto, Valentina; Sorarù, Gianni; Martinelli, Ilaria; Parchi, Piero; Liguori, Rocco; Mandrioli, Jessica
File in questo prodotto:
File Dimensione Formato  
13024_2020_Article_406.pdf

Open access

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 1.3 MB
Formato Adobe PDF
1.3 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1238775
Citazioni
  • ???jsp.display-item.citation.pmc??? 31
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 62
social impact