Background: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods: This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results: Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions: Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients / Canovi, S.; Besutti, G.; Bonelli, E.; Iotti, V.; Ottone, M.; Albertazzi, L.; Zerbini, A.; Pattacini, P.; Giorgi Rossi, P.; Colla, R.; Fasano, T.; Costantini, M.; Grilli, R.; Marino, M.; Formoso, G.; Formisano, D.; Rossi, P. G.; Bedeschi, E.; Perilli, C.; La Rosa, E.; Bisaccia, E.; Venturi, I.; Vicentini, M.; Campari, C.; Gioia, F.; Broccoli, S.; Spaggiari, L.; Mancuso, P.; Nitrosi, A.; Foracchia, M.; Massari, M.; Ferrari, A. M.; Pinotti, M.; Facciolongo, N.; Lattuada, I.; Trabucco, L.; De Pietri, S.; Danelli, G. F.; Bellesia, E.; Canovi, S.; Corradini, M.; Magnani, E.; Pilia, A.; Polese, A.; Incerti, S. S.; Zaldini, P.; Orsola, B.; Revelli, M.; Salvarani, C.; Pinto, C.; Venturelli, F.. - In: BMC INFECTIOUS DISEASES. - ISSN 1471-2334. - 21:1(2021), pp. 157-157. [10.1186/s12879-021-05855-9]